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Higher body mass index may be a predictor of extrathyroidal extension in patients with papillary thyroid microcarcinoma

Authors
 Ji Soo Choi  ;  Eun-Kyung Kim  ;  Hee Jung Moon  ;  Jin Young Kwak 
Citation
 ENDOCRINE, Vol.48(1) : 264-271, 2015 
Journal Title
ENDOCRINE
ISSN
 1355-008X 
Issue Date
2015
MeSH
Adult ; Aged ; Body Mass Index* ; Carcinoma, Papillary/diagnostic imaging ; Carcinoma, Papillary/pathology* ; Carcinoma, Papillary/surgery ; Endocrine Surgical Procedures ; Female ; Humans ; Lymphatic Metastasis/pathology ; Male ; Middle Aged ; Neoplasm Staging ; Prognosis ; Reference Standards ; Retrospective Studies ; Risk Factors ; Thyroid Neoplasms/diagnostic imaging ; Thyroid Neoplasms/pathology* ; Thyroid Neoplasms/surgery ; Thyrotropin/blood ; Ultrasonography
Keywords
Body mass index (BMI) ; Obesity ; Thyroid cancer ; Thyroid malignancy ; Extrathyroidal extension
Abstract
Recently, higher body mass index (BMI) has been associated with aggressive pathologic features of papillary thyroid carcinoma. The aim of this study was to clarify the relationship between BMI and aggressive pathologic features of papillary thyroid microcarcinoma (PTMC) and to evaluate whether the BMI can be a prognostic factor of PTMC. This retrospective study included 612 PTMC patients who underwent surgical excision at a referral center between April 2006 and December 2007. Patients were grouped according to BMI (<25 or ≥25 kg/m2). Multivariable logistic regression analysis was performed to determine independent predictors of aggressive pathologic features (advanced stage, extrathyroidal extension, and lymph node metastasis), with adjustment for age, gender, tumor size, multifocality, thyroid stimulating hormone (TSH) level, and BMI (value/group). PTMC patients with a BMI≥25 kg/m2 showed significantly higher prevalences of extrathyroidal extension, advanced pathologic TNM stage, and male gender, compared to those of patients with a BMI<25 kg/m2. Lymph node metastasis and mean TSH level were not significantly different between the two BMI subgroups. In multivariable analysis, the BMI≥25 kg/m2 group was positively associated with the presence of extrathyroidal extension (adjusted odds ratio 1.49, P=0.05). Higher BMI was associated with extrathyroidal extension in PTMC patients. This study suggests that the BMI could be considered as a prognostic factor for predicting the presence of extrathyroidal extension and it may help decide the appropriate surgical extent for PTMC patients.
Full Text
http://link.springer.com/article/10.1007%2Fs12020-014-0293-z
DOI
10.1007/s12020-014-0293-z
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Jin Young(곽진영) ORCID logo https://orcid.org/0000-0002-6212-1495
Kim, Eun-Kyung(김은경) ORCID logo https://orcid.org/0000-0002-3368-5013
Moon, Hee Jung(문희정) ORCID logo https://orcid.org/0000-0002-5643-5885
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139440
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