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Pseudo metal generation via catalytic oxidative polymerization on the surface of reactive template for redox switched off-on photothermal therapy

Authors
 Seo Ryung Bae  ;  Jihye Choi  ;  Hyun Ouk Kim  ;  Byunghoon Kang  ;  Myeong Hoon Kim  ;  Seungmin Han  ;  Ilkoo Noh  ;  Jong Woo Lim  ;  Jin Suk Suh  ;  Yong Min Huh  ;  Seungjoo Haam 
Citation
 Journal of Materials Chemistry B, Vol.3(3) : 505-513, 2015 
Journal Title
 Journal of Materials Chemistry B 
ISSN
 2050-750X 
Issue Date
2015
Abstract
The integration of contrast-enhanced diagnostic imaging and therapy could utilize image guided therapy to plan treatment strategy. Toward this goal, a unique construction and operation of a pseudo metal based photothermal therapeutic agent (PPAM) is introduced by polyaniline (PANI) generation templated on iron oxide metal nanoclusters (MNCs). Notably, MNC core interferes as a catalytic agent and enables aniline polymerization under ambient acidic conditions. The intrusion of transition metal enhanced the proton sensitivity of PANI, which led to pH responsive conversion even at dilute proton concentrations (pH 5, 6) compared to the PANI particles prepared by conventional methods. Under physiological pH, PPAM reveals no special features; however, under low pH conditions, which is a notable characteristic of the cancer microenvironment, PPAM automatically converts into its emeraldine salt (ES) state and thus activates as a photothermal therapeutic agent. Utilizing this specific redox responsive switched off–on behavior of PPAM, precise and systemized photothermal therapy is demonstrated, proving itself as a smart and efficient photothermal therapeutic agent.
Full Text
http://pubs.rsc.org/en/content/articlelanding/2015/tb/c4tb01461h#!divAbstract
DOI
10.1039/C4TB01461H
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
서진석(Suh, Jin Suck) ORCID logo https://orcid.org/0000-0001-9455-9240
허용민(Huh, Yong Min) ORCID logo https://orcid.org/0000-0002-9831-4475
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139399
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