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Sex differences in the relationship between blood mercury concentration and metabolic syndrome risk

Authors
 Ji-Youn Chung  ;  Min-Seok Seo  ;  Jae-Yong Shim  ;  Yong-Jae Lee 
Citation
 JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, Vol.38(1) : 65-71, 2015 
Journal Title
 JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION 
ISSN
 0391-4097 
Issue Date
2015
MeSH
Adult ; Biomarkers/blood ; Cross-Sectional Studies ; Female ; Humans ; Male ; Mercury/blood* ; Metabolic Syndrome/blood* ; Metabolic Syndrome/diagnosis* ; Metabolic Syndrome/epidemiology ; Middle Aged ; Nutrition Surveys/methods ; Republic of Korea/epidemiology ; Risk Factors ; Sex Characteristics*
Keywords
Mercury ; Metabolic syndrome ; Oxidative stress ; Sex differences
Abstract
BACKGROUND: Mercury exposure enhances free radical production and reduces activity of anti-oxidant enzymes, resulting in detrimental health effects. Some researchers have reported an association between blood mercury and increased risk of metabolic syndrome (MetS); however, sex differences in the relationship were not fully considered. AIM: To examine the sex differences in the relationship between blood mercury concentration and the increased risk of MetS in Korean men and women. MATERIALS AND METHODS: A nationwide cross-sectional study was conducted to examine the relationship between blood mercury concentration and MetS in 2,976 men and 3,074 women over 19 years of age (aged 19-87 years), using data from the 2010-2012 Korean National Health and Nutrition Examination Survey (KNHANES-V). Multiple logistic regression analysis was used to assess the relationship between blood mercury concentration and the prevalence risk of MetS after adjusting for confounding variables. RESULTS: Compared to the lowest quartile of blood mercury concentration, the OR (95 % CI) for MetS of the highest quartile in men was 1.62 (1.15-2.28) after adjusting for age, smoking status, alcohol consumption, regular exercise, and BMI. Similarly, in multiple logistic regression analysis using log2-transformed blood mercury as a continuous variable, the OR (95 % CI) for having MetS with doubling of blood mercury was 1.20 (1.05-1.36) after adjusting for the same co-variables. However, the relationship was not observed in women after adjusting for the same co-variables. CONCLUSIONS: Blood mercury concentration was independently associated with an increased risk of MetS in men.
Full Text
http://link.springer.com/article/10.1007%2Fs40618-014-0132-3
DOI
10.1007/s40618-014-0132-3
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Seo, Min Seok(서민석)
Shim, Jae Yong(심재용) ORCID logo https://orcid.org/0000-0002-9561-9230
Lee, Yong Jae(이용제) ORCID logo https://orcid.org/0000-0002-6697-476X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139351
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