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Effects of blood lead levels on airflow limitations in Korean adults: findings from the 5th KNHNES 2011

 Hye Kyung Chung  ;  Yoon Soo Chang  ;  Chul Woo Ahn 
 Environmental Research, Vol.136 : 274-279, 2015 
Journal Title
 Environmental Research 
Issue Date
Adult ; Female ; Humans ; Lead/blood* ; Male ; Middle Aged ; Republic of Korea ; Respiratory Function Tests
Airflow limitations ; FEV(1)/FVC ratio ; Heavy metals ; Lead ; Pulmonary function
This study aimed to examine whether blood levels of heavy metals, such as lead, mercury and cadmium, are related with pulmonary function in Korean adults. This investigation included 870 Korean adults (≥ 40 years) who received pulmonary function testing in the Korea National Health and Nutrition Examination Survey (KNHANES) V-2, 2011. Data of blood levels of heavy metals, pulmonary function tests and anthropometric measurements were acquired. Blood lead levels showed inverse correlations with the FEV1/FVC ratio before (r = -0.276, p < 0.001) and after adjustment of multiple compounding factors (r = -0.115, p = 0.001). A logistic multiple regression analysis revealed that blood lead levels were a significant influencing factor for the FEV1/FVC ratio (β = -0.017, p = 0.001, adjusted R(2) = 0.267). The odds ratios (ORs) for the FEV1/FVC ratio were significantly lower in the highest tertile group of the blood lead levels than in the lowest tertile group in Model 1 (OR = 0.007, 95% CI = 0.000-0.329) and Model 2 (OR = 0.006, 95% CI = 0.000-0.286). These findings imply that environmental exposure to lead might be an important factor that may cause airflow limitations in Korean adults.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Institute for Vascular and Metabolic Research (혈관대사연구소) > 1. Journal Papers
Yonsei Authors
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Chang, Yoon Soo(장윤수) ORCID logo https://orcid.org/0000-0003-3340-4223
Chung, Hye Kyung(정혜경)
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