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Neurocognitive function in children after anterior temporal lobectomy with amygdalohippocampectomy

Authors
 Yun-Jin Lee  ;  Hoon-Chul Kang  ;  Heung Dong Kim  ;  Dong-Seok Kim  ;  Kyu-Won Shim  ;  Soyong Eom  ;  Joon Soo Lee 
Citation
 PEDIATRIC NEUROLOGY, Vol.52(1) : 88-93, 2015 
Journal Title
 PEDIATRIC NEUROLOGY 
ISSN
 0887-8994 
Issue Date
2015
MeSH
Amygdala/surgery* ; Anterior Temporal Lobectomy/methods* ; Child ; Epilepsy, Temporal Lobe/drug therapy ; Epilepsy, Temporal Lobe/psychology* ; Epilepsy, Temporal Lobe/surgery* ; Female ; Follow-Up Studies ; Functional Laterality ; Hippocampus/surgery* ; Humans ; Intelligence ; Intelligence Tests ; Male ; Memory ; Neuropsychological Tests ; Retrospective Studies ; Temporal Lobe/surgery* ; Treatment Outcome
Keywords
anterior temporal lobectomy ; child ; intelligence ; memory ; temporal lobe epilepsy
Abstract
BACKGROUND: We assessed the postoperative neurocognitive function after temporal lobectomy in children with temporal lobe epilepsy. METHODS: This was a retrospective analysis of the data of 20 patients with Engel's class I or II outcomes after anterior temporal lobectomy with amygdalohippocampectomy between 2005 and 2008. Twenty children underwent resection of either dominant (n = 8) or nondominant (n = 12) temporal lobes, and their median age at surgery was 12.8 ± 3.2 years. We serially assessed intelligence and memory function as measured by the Korean-Wechsler Scales of Intelligence and Rey-Kim Memory test both before and after surgery. RESULTS: Intelligence quotient (IQ) and memory quotient scores remained stable during a 3.6-year median follow-up in these children after the surgery. There was no decrease of IQ or memory quotient scores in either the dominant or non-dominant hemisphere groups. Later onset of epilepsy, a shorter epilepsy duration, a smaller number of antiepileptic drugs, and postoperative seizure-free outcomes were significant good predictors of the postoperative IQ. CONCLUSION: Temporal lobectomy in children did not provoke a significant decline in intelligence or memory function. Early surgical treatment in children with intractable seizures of temporal lobe origin may result in better neurocognitive outcomes.
Full Text
http://www.sciencedirect.com/science/article/pii/S088789941400575X
DOI
10.1016/j.pediatrneurol.2014.09.006
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Epilepsy Research Institute (뇌전증연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Hoon Chul(강훈철) ORCID logo https://orcid.org/0000-0002-3659-8847
Kim, Dong Seok(김동석)
Kim, Heung Dong(김흥동) ORCID logo https://orcid.org/0000-0002-8031-7336
Shim, Kyu Won(심규원) ORCID logo https://orcid.org/0000-0002-9441-7354
Eom, So Yong(엄소용)
Lee, Joon Soo(이준수) ORCID logo https://orcid.org/0000-0001-9036-9343
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139184
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