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Neurophysiologic correlates of sonication treatment in patients with essential tremor

Authors
 Jin Woo Chang  ;  Byoung-Kyong Min  ;  Bong-Soo Kim  ;  Won Seok Chang  ;  Yong-Ho Lee 
Citation
 ULTRASOUND IN MEDICINE AND BIOLOGY, Vol.41(1) : 124-131, 2015 
Journal Title
ULTRASOUND IN MEDICINE AND BIOLOGY
ISSN
 0301-5629 
Issue Date
2015
MeSH
Aged ; Brain Waves* ; Essential Tremor/diagnosis* ; Essential Tremor/physiopathology ; Essential Tremor/surgery* ; Feasibility Studies ; High-Intensity Focused Ultrasound Ablation/methods* ; Humans ; Intraoperative Neurophysiological Monitoring/methods* ; Magnetic Resonance Imaging, Interventional/methods* ; Magnetoencephalography* ; Male ; Middle Aged ; Treatment Outcome
Keywords
Essential tremor ; Magnetic resonance imaging-guided high-intensity focused ultrasound ; Magnetoencephalography ; Mu rhythm ; Thalamus
Abstract
Transcranial magnetic resonance imaging-guided high-intensity focused ultrasound (MRgHIFU) is gaining attention as a potent substitute for surgical intervention in the treatment of neurologic disorders. To discern the neurophysiologic correlates of its therapeutic effects, we applied MRgHIFU to an intractable neurologic disorder, essential tremor, while measuring magnetoencephalogram mu rhythms from the motor cortex. Focused ultrasound sonication destroyed tissues by focusing a high-energy beam on the ventralis intermedius nucleus of the thalamus. The post-treatment effectiveness was also evaluated using the clinical rating scale for tremors. Thalamic MRgHIFU had substantial therapeutic effects on patients, based on MRgHIFU-mediated improvements in movement control and significant changes in brain mu rhythms. Ultrasonic thalamotomy may reduce hyper-excitable activity in the motor cortex, resulting in normalized behavioral activity after sonication treatment. Thus, non-invasive and spatially accurate MRgHIFU technology can serve as a potent therapeutic tool with broad clinical applications.
Full Text
http://www.sciencedirect.com/science/article/pii/S0301562914005262
DOI
10.1016/j.ultrasmedbio.2014.08.008
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Bong Soo(김봉수)
Chang, Won Seok(장원석) ORCID logo https://orcid.org/0000-0003-3145-4016
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139176
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