Cited 14 times in
Neurophysiologic correlates of sonication treatment in patients with essential tremor
DC Field | Value | Language |
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dc.contributor.author | 김봉수 | - |
dc.contributor.author | 장원석 | - |
dc.contributor.author | 장진우 | - |
dc.date.accessioned | 2016-02-04T10:52:39Z | - |
dc.date.available | 2016-02-04T10:52:39Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0301-5629 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/139176 | - |
dc.description.abstract | Transcranial magnetic resonance imaging-guided high-intensity focused ultrasound (MRgHIFU) is gaining attention as a potent substitute for surgical intervention in the treatment of neurologic disorders. To discern the neurophysiologic correlates of its therapeutic effects, we applied MRgHIFU to an intractable neurologic disorder, essential tremor, while measuring magnetoencephalogram mu rhythms from the motor cortex. Focused ultrasound sonication destroyed tissues by focusing a high-energy beam on the ventralis intermedius nucleus of the thalamus. The post-treatment effectiveness was also evaluated using the clinical rating scale for tremors. Thalamic MRgHIFU had substantial therapeutic effects on patients, based on MRgHIFU-mediated improvements in movement control and significant changes in brain mu rhythms. Ultrasonic thalamotomy may reduce hyper-excitable activity in the motor cortex, resulting in normalized behavioral activity after sonication treatment. Thus, non-invasive and spatially accurate MRgHIFU technology can serve as a potent therapeutic tool with broad clinical applications. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 124~131 | - |
dc.relation.isPartOf | ULTRASOUND IN MEDICINE AND BIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Brain Waves* | - |
dc.subject.MESH | Essential Tremor/diagnosis* | - |
dc.subject.MESH | Essential Tremor/physiopathology | - |
dc.subject.MESH | Essential Tremor/surgery* | - |
dc.subject.MESH | Feasibility Studies | - |
dc.subject.MESH | High-Intensity Focused Ultrasound Ablation/methods* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Intraoperative Neurophysiological Monitoring/methods* | - |
dc.subject.MESH | Magnetic Resonance Imaging, Interventional/methods* | - |
dc.subject.MESH | Magnetoencephalography* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Neurophysiologic correlates of sonication treatment in patients with essential tremor | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurosurgery (신경외과학) | - |
dc.contributor.googleauthor | Jin Woo Chang | - |
dc.contributor.googleauthor | Byoung-Kyong Min | - |
dc.contributor.googleauthor | Bong-Soo Kim | - |
dc.contributor.googleauthor | Won Seok Chang | - |
dc.contributor.googleauthor | Yong-Ho Lee | - |
dc.identifier.doi | 10.1016/j.ultrasmedbio.2014.08.008 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03454 | - |
dc.contributor.localId | A00515 | - |
dc.contributor.localId | A03484 | - |
dc.relation.journalcode | J02769 | - |
dc.identifier.eissn | 1879-291X | - |
dc.identifier.pmid | 25438838 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0301562914005262 | - |
dc.subject.keyword | Essential tremor | - |
dc.subject.keyword | Magnetic resonance imaging-guided high-intensity focused ultrasound | - |
dc.subject.keyword | Magnetoencephalography | - |
dc.subject.keyword | Mu rhythm | - |
dc.subject.keyword | Thalamus | - |
dc.contributor.alternativeName | Kim, Bong Soo | - |
dc.contributor.alternativeName | Chang, Won Seok | - |
dc.contributor.alternativeName | Chang, Jin Woo | - |
dc.contributor.affiliatedAuthor | Chang, Won Seok | - |
dc.contributor.affiliatedAuthor | Kim, Bong Soo | - |
dc.contributor.affiliatedAuthor | Chang, Jin Woo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 41 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 124 | - |
dc.citation.endPage | 131 | - |
dc.identifier.bibliographicCitation | ULTRASOUND IN MEDICINE AND BIOLOGY, Vol.41(1) : 124-131, 2015 | - |
dc.identifier.rimsid | 43812 | - |
dc.type.rims | ART | - |
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