142 148

Cited 1 times in

Effect of endogenous bone marrow derived stem cells induced by AMD-3100 on expanded ischemic flap.

Authors
 Hii Sun Jeong  ;  Hye Kyung Lee  ;  Kwan Chul Tark  ;  Dae Hyun Lew  ;  Yoon Woo Koh  ;  Chul Hoon Kim  ;  In Suck Seo 
Citation
 Journal of Korean Medical Science, Vol.29(Suppl 3) : 237-248, 2014 
Journal Title
 Journal of Korean Medical Science 
ISSN
 1011-8934 
Issue Date
2014
Abstract
The purpose of this study was to devise an expanded ischemic flap model and to investigate the role of AMD-3100 (Plerixafor, chemokine receptor 4 inhibitor) in this model by confirming its effect on mobilization of stem cells from the bone marrow. Male Sprague-Dawley rats were used as an animal research model. The mobilization of stem cells from the bone marrow was confirmed in the AMD-3100-treated group. The fractions of endothelial progenitor cells (EPC) and the vascular endothelial growth factor receptor (VEGFR) 2+ cells in the peripheral blood were increased in groups treated with AMD-3100. The expression of vascular endothelial growth factor (VEGF) was increased in response to expansion or AMD injection. The expression of stromal cell derived factor (SDF)-1 and VEGFR2 were increased only in unexpanded flap treated with AMD-3100. Treatment with AMD-3100 increased both the number and area of blood vessels. However, there were no statistically significant differences in the survival area or physiologic microcirculation in rats from the other groups. This endogenous neovascularization induced by AMD-3100 may be a result of the increase in both the area and number of vessels, as well as paracrine augmentation of the expression of VEGF and EPCs. However, the presence of a tissue expander under the flap could block the neovascularization between the flap and the recipient regardless of AMD-3100 treatment and expansion.
Files in This Item:
T201405767.pdf Download
DOI
10.3346/jkms.2014.29.S3.S237
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
고윤우(Kho, Yoon Woo)
김철훈(Kim, Chul Hoon) ORCID logo https://orcid.org/0000-0002-7360-429X
유대현(Lew, Dae Hyun)
탁관철(Tark, Kwan Chul)
Export
RIS (EndNote)
XLS (Excel)
XML
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/138872
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse