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Is microsatellite instability a prognostic marker in gastric cancer? A systematic review with meta-analysis.

Authors
 Yoon Young Choi  ;  Jung Min Bae  ;  Ji Yeong An  ;  In Gyu Kwon  ;  In Cho  ;  Hyun Beak Shin  ;  Tanaka Eiji  ;  Mohammad Aburahmah  ;  Hyung Il Kim  ;  Jae Ho Cheong  ;  Woo Jin Hyung  ;  Sung Hoon Noh 
Citation
 JOURNAL OF SURGICAL ONCOLOGY, Vol.110(2) : 129-135, 2014 
Journal Title
 JOURNAL OF SURGICAL ONCOLOGY 
ISSN
 0022-4790 
Issue Date
2014
MeSH
Adenocarcinoma/genetics* ; Adenocarcinoma/mortality* ; Genetic Markers ; Humans ; Microsatellite Instability* ; Models, Statistical ; Prognosis ; Stomach Neoplasms/genetics* ; Stomach Neoplasms/mortality* ; Survival Analysis
Keywords
MSI ; gastric cancer ; prognosis
Abstract
BACKGROUND AND OBJECTIVE: The relationship between survival in gastric cancer patients and the status of microsatellite instability (MSI) has not yet been established. The purpose of this meta-analysis was to obtain integrated and more precise data for the value of MSI as a prognostic marker in gastric cancer. METHODS: A comprehensive systematic review and meta-analysis were conducted using major electronic databases (PubMed, EMBASE, and the Cochrane Central) with keywords related to "microsatellite instability," "gastric cancer," and "prognosis." RESULTS: Twenty-four studies with 5,438 participants (712 cases were MSI gastric cancer) were included for pooling risk estimates of MSI in gastric cancer. Seventeen studies reported overall survival. The pooled hazard ratio (HR) for overall survival of MSI vs. non-MSI was 0.72 (95%CI: 0.59-0.88, P = .001) in a random-effects model. In the sensitivity analysis, the result from the most recent study showed the most heterogeneity. CONCLUSION: MSI gastric cancer was associated with good prognosis but there was heterogeneity in the recent studies. Changed epidemiology and effects of chemotherapy are potential causes of heterogeneity. Establishing a consensus for defining MSI in gastric cancer should be preferred for future studies.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/jso.23618/abstract
DOI
10.1002/jso.23618
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, In Gyu(권인규) ORCID logo https://orcid.org/0000-0002-1489-467X
Kim, Hyoung Il(김형일) ORCID logo https://orcid.org/0000-0002-6134-4523
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
Shin, Hyun Beak(신현백)
Cheong, Jae Ho(정재호) ORCID logo https://orcid.org/0000-0002-1703-1781
Cho, In(조인)
Choi, Yoon Young(최윤영) ORCID logo https://orcid.org/0000-0002-2179-7851
Hyung, Woo Jin(형우진) ORCID logo https://orcid.org/0000-0002-8593-9214
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/138858
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