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Is microsatellite instability a prognostic marker in gastric cancer? A systematic review with meta-analysis.

DC FieldValueLanguage
dc.contributor.author권인규-
dc.contributor.author김형일-
dc.contributor.author노성훈-
dc.contributor.author신현백-
dc.contributor.author안지영-
dc.contributor.author정재호-
dc.contributor.author조인-
dc.contributor.author형우진-
dc.contributor.author최윤영-
dc.date.accessioned2015-12-28T11:10:32Z-
dc.date.available2015-12-28T11:10:32Z-
dc.date.issued2014-
dc.identifier.issn0022-4790-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/138858-
dc.description.abstractBACKGROUND AND OBJECTIVE: The relationship between survival in gastric cancer patients and the status of microsatellite instability (MSI) has not yet been established. The purpose of this meta-analysis was to obtain integrated and more precise data for the value of MSI as a prognostic marker in gastric cancer. METHODS: A comprehensive systematic review and meta-analysis were conducted using major electronic databases (PubMed, EMBASE, and the Cochrane Central) with keywords related to "microsatellite instability," "gastric cancer," and "prognosis." RESULTS: Twenty-four studies with 5,438 participants (712 cases were MSI gastric cancer) were included for pooling risk estimates of MSI in gastric cancer. Seventeen studies reported overall survival. The pooled hazard ratio (HR) for overall survival of MSI vs. non-MSI was 0.72 (95%CI: 0.59-0.88, P = .001) in a random-effects model. In the sensitivity analysis, the result from the most recent study showed the most heterogeneity. CONCLUSION: MSI gastric cancer was associated with good prognosis but there was heterogeneity in the recent studies. Changed epidemiology and effects of chemotherapy are potential causes of heterogeneity. Establishing a consensus for defining MSI in gastric cancer should be preferred for future studies.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfJOURNAL OF SURGICAL ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenocarcinoma/genetics*-
dc.subject.MESHAdenocarcinoma/mortality*-
dc.subject.MESHGenetic Markers-
dc.subject.MESHHumans-
dc.subject.MESHMicrosatellite Instability*-
dc.subject.MESHModels, Statistical-
dc.subject.MESHPrognosis-
dc.subject.MESHStomach Neoplasms/genetics*-
dc.subject.MESHStomach Neoplasms/mortality*-
dc.subject.MESHSurvival Analysis-
dc.titleIs microsatellite instability a prognostic marker in gastric cancer? A systematic review with meta-analysis.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthorYoon Young Choi-
dc.contributor.googleauthorJung Min Bae-
dc.contributor.googleauthorJi Yeong An-
dc.contributor.googleauthorIn Gyu Kwon-
dc.contributor.googleauthorIn Cho-
dc.contributor.googleauthorHyun Beak Shin-
dc.contributor.googleauthorTanaka Eiji-
dc.contributor.googleauthorMohammad Aburahmah-
dc.contributor.googleauthorHyung Il Kim-
dc.contributor.googleauthorJae Ho Cheong-
dc.contributor.googleauthorWoo Jin Hyung-
dc.contributor.googleauthorSung Hoon Noh-
dc.identifier.doi10.1002/jso.23618-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00243-
dc.contributor.localIdA01154-
dc.contributor.localIdA01281-
dc.contributor.localIdA02173-
dc.contributor.localIdA03717-
dc.contributor.localIdA03889-
dc.contributor.localIdA04382-
dc.relation.journalcodeJ01762-
dc.identifier.eissn1096-9098-
dc.identifier.pmid24737677-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1002/jso.23618/abstract-
dc.subject.keywordMSI-
dc.subject.keywordgastric cancer-
dc.subject.keywordprognosis-
dc.contributor.alternativeNameKwon, In Gyu-
dc.contributor.alternativeNameKim, Hyoung Il-
dc.contributor.alternativeNameNoh, Sung Hoon-
dc.contributor.alternativeNameShin, Hyun Beak-
dc.contributor.alternativeNameAn, Ji Yeong-
dc.contributor.alternativeNameCheong, Jae Ho-
dc.contributor.alternativeNameCho, In-
dc.contributor.alternativeNameHyung, Woo Jin-
dc.contributor.affiliatedAuthorKwon, In Gyu-
dc.contributor.affiliatedAuthorKim, Hyoung Il-
dc.contributor.affiliatedAuthorNoh, Sung Hoon-
dc.contributor.affiliatedAuthorShin, Hyun Beak-
dc.contributor.affiliatedAuthorCheong, Jae Ho-
dc.contributor.affiliatedAuthorCho, In-
dc.contributor.affiliatedAuthorHyung, Woo Jin-
dc.rights.accessRightsfree-
dc.citation.volume110-
dc.citation.number2-
dc.citation.startPage129-
dc.citation.endPage135-
dc.identifier.bibliographicCitationJOURNAL OF SURGICAL ONCOLOGY, Vol.110(2) : 129-135, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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