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Trans-ethnic study confirmed independent associations of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe ocular surface complications

 Mayumi Ueta  ;  Chitra Kannabiran  ;  Tais Hitomi Wakamatsu  ;  Mee Kum Kim  ;  Kyung Chul Yoon  ;  Kyoung Yul Seo  ;  Choun Ki Joo  ;  Virender Sangwan  ;  Varsha Rathi  ;  Sayan Basu  ;  Almas Shamaila  ;  Hyo Seok Lee  ;  Sangchul Yoon  ;  Chie Sotozono  ;  José Álvaro Pereira Gomes  ;  Katsushi Tokunaga  ;  Shigeru Kinoshita 
 SCIENTIFIC REPORTS, Vol.4 : 5981, 2014 
Journal Title
Issue Date
Adolescent ; Adult ; Alleles ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Brazil ; Child ; Dry Eye Syndromes/ethnology ; Dry Eye Syndromes/etiology ; Dry Eye Syndromes/genetics* ; Dry Eye Syndromes/immunology ; Epithelium, Corneal/immunology ; Epithelium, Corneal/pathology ; Ethnic Groups ; Female ; Gene Frequency ; HLA-A2 Antigen/genetics* ; HLA-A2 Antigen/immunology ; HLA-B44 Antigen/genetics* ; HLA-B44 Antigen/immunology ; Humans ; India ; Male ; Middle Aged ; Multi-Ingredient Cold, Flu, and Allergy Medications/adverse effects ; Republic of Korea ; Retinal Pigment Epithelium/immunology ; Retinal Pigment Epithelium/pathology ; Risk Factors ; Stevens-Johnson Syndrome/ethnology ; Stevens-Johnson Syndrome/etiology ; Stevens-Johnson Syndrome/genetics* ; Stevens-Johnson Syndrome/immunology ; Trichiasis/ethnology ; Trichiasis/etiology ; Trichiasis/genetics* ; Trichiasis/immunology
Stevens-Johnson syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN), are acute inflammatory vesiculobullous reactions of the skin and mucous membranes. Cold medicines including non-steroidal anti-inflammatory drugs and multi-ingredient cold medications are reported to be important inciting drugs. Recently, we reported that cold medicine related SJS/TEN (CM-SJS/TEN) with severe mucosal involvement including severe ocular surface complications (SOC) is associated with HLA-A*02:06 and HLA-B*44:03 in the Japanese. In this study, to determine whether HLA-B*44:03 is a common risk factor for CM-SJS/TEN with SOC in different ethnic groups we used samples from Indian, Brazilian, and Korean patients with CM-SJS/TEN with SOC, and investigated the association between CM-SJS/TEN with SOC and HLA-B*44:03 and/or HLA-A*02:06. We found that HLA-B*44:03 was significantly associated with CM-SJS/TEN with SOC in the Indian and Brazilian but not the Korean population, and that HLA-A*02:06 might be weakly associated in the Korean- but not the Indian and Brazilian population.
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1. College of Medicine (의과대학) > Dept. of Medical Humanities and Social Sciences (인문사회의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Seo, Kyoung Yul(서경률) ORCID logo https://orcid.org/0000-0002-9855-1980
Yoon, Sang Chul(윤상철) ORCID logo https://orcid.org/0000-0003-0454-9597
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