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Contrasting roles of different endoglin forms in atherosclerosis.

Authors
 Young Saeng Jang  ;  In Hong Choi 
Citation
 Immune Network, Vol.14(5) : 237-240, 2014 
Journal Title
 Immune Network 
ISSN
 1598-2629 
Issue Date
2014
Abstract
Endoglin (also known as CD105 or TGF-β type III receptor) is a co-receptor involved in TGF-β signaling. In atherosclerosis, TGF-β signaling is crucial in regulating disease progression owing to its anti-inflammatory effects as well as its inhibitory effects on smooth muscle cell proliferation and migration. Endoglin is a regulator of TGF-β signaling, but its role in atherosclerosis has yet to be defined. This review focuses on the roles of the various forms of endoglin in atherosclerosis. The expression of the two isoforms of endoglin (long-form and short-form) is increased in atherosclerotic lesions, and the expression of the soluble forms of endoglin is upregulated in sera of patients with hypercholesterolemia and atherosclerosis. Interestingly, long-form endoglin shows an atheroprotective effect via the induction of eNOS expression, while short-form and soluble endoglin enhance atherogenesis by inhibiting eNOS expression and TGF-β signaling. This review summarizes evidence suggesting that the different forms of endoglin have distinct roles in atherosclerosis.
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T201405544.pdf Download
DOI
10.4110/in.2014.14.5.237
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실)
Yonsei Authors
장영생(Jang, Young Saeng)
최인홍(Choi, In Hong) ORCID logo https://orcid.org/0000-0001-9851-0137
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/138739
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