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Evaluation of extracellular volume fraction thresholds corresponding to myocardial late-gadolinium enhancement using cardiac magnetic resonance.

Authors
 Sung Ho Hwang  ;  Eui Young Choi  ;  Chul Hwan Park  ;  Mun Young Paek  ;  Andreas Greiser  ;  Tae Hoon Kim  ;  Byoung Wook Choi 
Citation
 International Journal of Cardiovascular Imaging, Vol.30(Suppl 2) : 137-144, 2014 
Journal Title
 International Journal of Cardiovascular Imaging 
ISSN
 1569-5794 
Issue Date
2014
Abstract
To establish extracellular volume fraction (ECV) thresholds corresponding to myocardial lesion detected by late-gadolinium enhancement (LGE) cardiac magnetic resonance (CMR) imaging. Fifty-six patients with myocardial infarction or hypertrophic cardiomyopathy underwent LGE, pre- and post-contrast modified Look-Locker inversion recovery (MOLLI) sequences on a 3-T CMR system. Short-axis MOLLI images generated ECV maps of left ventricular (LV) walls. The LGE areas were semi-automatically determined by different signal threshold techniques. The areas of elevated ECV were measured using ECV thresholds of 28-48%. The LGE areas were compared with the areas of elevated ECV at the corresponding LV levels. The myocardial areas of LGE and elevated ECVs showed a strong and positive correlation (P < 0.01). The LGE threshold, set at two standard deviations above the mean signal from the remote myocardium, corresponded well with the area of ECV >32%. When using the full width at half-maximum (FWHM) technique, the LGE area corresponded well with the area of ECV >42 or 44%. By applying particular ECV thresholds, myocardial ECV maps can define myocardial status equivalent to LGE, and definite ECV thresholds may be useful for the straightforward evaluation of myocardial phenotypes.
Full Text
http://link.springer.com/article/10.1007/s10554-014-0489-6
DOI
10.1007/s10554-014-0489-6
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
김태훈(Kim, Tae Hoon) ORCID logo https://orcid.org/0000-0003-3598-2529
박철환(Park, Chul Hwan) ORCID logo https://orcid.org/0000-0002-0004-9475
최병욱(Choi, Byoung Wook) ORCID logo https://orcid.org/0000-0002-8873-5444
최의영(Choi, Eui Young) ORCID logo https://orcid.org/0000-0003-3732-0190
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/138698
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