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Evaluation of extracellular volume fraction thresholds corresponding to myocardial late-gadolinium enhancement using cardiac magnetic resonance.

 Sung Ho Hwang  ;  Eui Young Choi  ;  Chul Hwan Park  ;  Mun Young Paek  ;  Andreas Greiser  ;  Tae Hoon Kim  ;  Byoung Wook Choi 
 International Journal of Cardiovascular Imaging, Vol.30(Suppl 2) : 137-144, 2014 
Journal Title
 International Journal of Cardiovascular Imaging 
Issue Date
To establish extracellular volume fraction (ECV) thresholds corresponding to myocardial lesion detected by late-gadolinium enhancement (LGE) cardiac magnetic resonance (CMR) imaging. Fifty-six patients with myocardial infarction or hypertrophic cardiomyopathy underwent LGE, pre- and post-contrast modified Look-Locker inversion recovery (MOLLI) sequences on a 3-T CMR system. Short-axis MOLLI images generated ECV maps of left ventricular (LV) walls. The LGE areas were semi-automatically determined by different signal threshold techniques. The areas of elevated ECV were measured using ECV thresholds of 28-48%. The LGE areas were compared with the areas of elevated ECV at the corresponding LV levels. The myocardial areas of LGE and elevated ECVs showed a strong and positive correlation (P < 0.01). The LGE threshold, set at two standard deviations above the mean signal from the remote myocardium, corresponded well with the area of ECV >32%. When using the full width at half-maximum (FWHM) technique, the LGE area corresponded well with the area of ECV >42 or 44%. By applying particular ECV thresholds, myocardial ECV maps can define myocardial status equivalent to LGE, and definite ECV thresholds may be useful for the straightforward evaluation of myocardial phenotypes.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
김태훈(Kim, Tae Hoon) ORCID logo https://orcid.org/0000-0003-3598-2529
박철환(Park, Chul Hwan) ORCID logo https://orcid.org/0000-0002-0004-9475
최병욱(Choi, Byoung Wook) ORCID logo https://orcid.org/0000-0002-8873-5444
최의영(Choi, Eui Young) ORCID logo https://orcid.org/0000-0003-3732-0190
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