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Dual-energy cardiac computed tomography for differentiating cardiac myxoma from thrombus

 Yoo Jin Hong  ;  Jin Hur  ;  Young Jin Kim  ;  Hye Jeong Lee  ;  Sae Rom Hong  ;  Young Joo Suh  ;  Hee Yeong Kim  ;  Ji Won Lee  ;  Byoung Wook Choi 
 International Journal of Cardiovascular Imaging, Vol.30(Suppl 2) : 121-128, 2014 
Journal Title
 International Journal of Cardiovascular Imaging 
Issue Date
Aged ; Contrast Media ; Diagnosis, Differential ; Female ; Heart Neoplasms/diagnostic imaging* ; Humans ; Iopamidol ; Male ; Middle Aged ; Multidetector Computed Tomography* ; Myxoma/diagnosis* ; Predictive Value of Tests ; Prospective Studies ; Thrombosis/diagnostic imaging*
Dual-energy computed tomography (DECT) ; Cardiac myxoma ; Cardiac thrombus ; Differential diagnosis
Although intra-cardiac masses are rare, diagnosis and refined characterization of these masses are important because of the different therapeutic strategies used to treat these lesions. The purpose of this study was to evaluate the diagnostic value of dual-energy cardiac computed tomography (CCT) for differentiating cardiac myxomas from thrombi. Our institutional review board approved this study, and patients provided informed consent. We prospectively enrolled 37 patients who had an intra-cardiac mass on echocardiography or computed tomography (CT). All patients underwent dual-energy CCT. For quantitative analysis, the CT attenuation density and iodine concentration of the intra-cardiac mass were measured on CT images. The Mann-Whitney test was used to evaluate differences in the mean CT attenuation density and the mean iodine concentrations between the cardiac myxoma and thrombus groups. Pathological results or follow-up with echocardiography was used to make the final diagnosis. There were a total of 17 cardiac myxomas and 20 thrombi. On CT, the mean CT numbers were not significantly different between cardiac myxomas and cardiac thrombi (91.7 ± 11.6 HU vs. 85.2 ± 10.9 HU, respectively, P = 0.241), whereas, the mean iodine concentration (mg/ml) was significantly different between cardiac myxomas and cardiac thrombi (3.53 ± 0.72 vs. 1.37 ± 0.31, respectively, P < 0.001). Dual-energy CCT using a quantitative analytic methodology can be used to differentiate between cardiac myxomas and thrombi.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Jin(김영진) ORCID logo https://orcid.org/0000-0002-6235-6550
Suh, Young Joo(서영주) ORCID logo https://orcid.org/0000-0002-2078-5832
Lee, Hye Jeong(이혜정) ORCID logo https://orcid.org/0000-0003-4349-9174
Choi, Byoung Wook(최병욱) ORCID logo https://orcid.org/0000-0002-8873-5444
Hur, Jin(허진) ORCID logo https://orcid.org/0000-0002-8651-6571
Hong, Sae Rom(홍새롬)
Hong, Yoo Jin(홍유진) ORCID logo https://orcid.org/0000-0002-7276-0944
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