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Complete Genome Sequence of the Siphoviral Bacteriophage YMC/09/04/R1988 MRSA BP: A lytic phage from a methicillin-resistant Staphylococcus aureus isolate.

Authors
 Jongsoo Jeon  ;  Roshan D'Souza  ;  Sung Kuk Hong  ;  Yangsoon Lee  ;  Dongeun Yong  ;  Jongrak Choi  ;  Kyungwon Lee  ;  Yunsop Chong 
Citation
 FEMS MICROBIOLOGY LETTERS, Vol.359(2) : 144-146, 2014 
Journal Title
 FEMS MICROBIOLOGY LETTERS 
ISSN
 0378-1097 
Issue Date
2014
Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) is an increasing cause of serious infection, both in the community and hospital settings. Despite sophisticated strategies and efforts, the antibiotic options for treating MRSA infection have been narrowed due to the limited number of newly developed antimicrobials. Herein, we analyze the completely sequenced genome of a novel virulent phage YMC/09/04/R1988 MRSA BP as a potential alternative anti-MRSA agent, which lysed clinical isolates from a patient admitted to the hospital due to hip disarticulation. The phage contains a linear double-stranded DNA genome of 44,459 bp in length, with 33.37% GC content, 62 predicted open reading frames (ORFs), and annotated functions of only 23 ORFs that are associated with structural assembly, host lysis, DNA replication, and modification. It showed a broad host range (17 of 30 strains) against MRSA strains in clinical isolates.
Files in This Item:
T201404794.pdf Download
DOI
10.1111/1574-6968.12580
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
Lee, Yang Soon(이양순)
Jeon, Jong Soo(전종수) ORCID logo https://orcid.org/0000-0002-7213-5663
Chong, Yun Sop(정윤섭)
Choi, Jong Rak(최종락) ORCID logo https://orcid.org/0000-0002-0608-2989
Hong, Sung Kuk(홍성극)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/138546
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