137 213

Cited 0 times in

Islet Encapsulation Using Chondrocyte

 Jeong Ik Lee  ;  Joon Ye Kim  ;  Jae Geun Lee  ;  Yu Seun Kim 
 Journal of the Korean Society for Transplantation (대한이식학회지), Vol.28(4) : 187-194, 2014 
Journal Title
 Journal of the Korean Society for Transplantation (대한이식학회지) 
Issue Date
Islet transplantation ; Immunoisolation ; Chondrocyte ; Encapsulation
Diabetes mellitus is one of the leading metabolic diseases that cause an increasing rate of mortality and morbidity. Recently, rather than the current drug treatment, pancreatic islet transplantation has been regarded as a potentially promising strategy for insulin- dependent diabetes mellitus while preventing complications such as kidney damage, vascular damage, nerve damage, and blindness. Recently, a number of advanced islet encapsulation techniques have been designed to enhance the efficiency of islet transplantation, including cell sheet engineering and generation of 3D islet spheroids by high density suspension system (HDSS). Chondrocytes derived from cartilage sources have been used as an encapsulation biomaterial for islets not only for autograft but also for allograft and xenograft transplantation. Cartilage is an avascular, white connective tissue that is rich in extracellular matrix, and expandable in vitro. Hence, this tissue might have immunologically privileged properties that make it an intelligent cell source for manufacture of encapsulation biomaterials. However, cell sheet engineering and HDSS still have their respective limitations, which need to be elucidated. This review will describe the advantages and disadvantages of the current encapsulation techniques in order to provide a comprehensive foundation for further modifications and improvements of tissue engineering for islet transplantation.
Files in This Item:
T201404786.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Yu Seun(김유선) ORCID logo https://orcid.org/0000-0002-5105-1567
Kim, Joon Ye(김준예)
Lee, Jae Geun(이재근) ORCID logo https://orcid.org/0000-0002-6722-0257
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.