Cited 3 times in
Differential association between obesity and coronary artery disease according to the presence of diabetes in a Korean population
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김영진 | - |
dc.contributor.author | 성지민 | - |
dc.contributor.author | 심지영 | - |
dc.contributor.author | 원기범 | - |
dc.contributor.author | 장혁재 | - |
dc.contributor.author | 정남식 | - |
dc.contributor.author | 조인정 | - |
dc.contributor.author | 최병욱 | - |
dc.contributor.author | 홍그루 | - |
dc.date.accessioned | 2015-12-28T11:00:34Z | - |
dc.date.available | 2015-12-28T11:00:34Z | - |
dc.date.issued | 2014 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/138497 | - |
dc.description.abstract | BACKGROUND: Coronary artery disease (CAD) is a major cardiovascular complication in diabetic patients. Despite the significant association between obesity and diabetes, the majority of the diabetic subjects are not obese in an Asian population. This study evaluated the association between obesity and coronary artery disease (CAD) according to the diabetes status in a Korean population. METHODS: The association between obesity and CAD using the parameters of any plaque, obstructive plaque, and coronary artery calcium score (CACS) >100 according to the presence of diabetes was evaluated in 7,234 Korean adults who underwent multi-detector computed tomography for general health evaluations. Obesity was defined as a body mass index (BMI) ≥25 kg/m(2). RESULTS: The prevalence of obesity was significantly higher in diabetic subjects than in non-diabetic subjects, but the majority of the diabetic subjects were non-obese (48% vs. 37%, p <0.001). The incidence of any plaque (58% vs. 29%), obstructive plaque (20% vs. 6%), and CACS >100 (20% vs. 6%) were significantly higher in diabetic patients than in non-diabetic subjects (p <0.001, respectively). Incidence of any plaque (33% vs. 26%, p <0.001), obstructive plaque (7% vs. 6%, p = 0.014), and CACS >100 (8% vs. 6%, p = 0.002) was significantly higher in non-diabetic subjects with obesity than in those without obesity, but the incidence of all coronary parameters was not different in diabetic subjects according to the obesity status. After adjusting for confounding risk factors including age, gender, hypertension, dyslipidemia, current smoking, and mild renal dysfunction, obesity was independently associated with increased risks of any plaque (OR 1.14) and CACS >100 (OR 1.31) only in non-diabetic subjects (p <0.05, respectively). Multiple logistic regression models revealed that diabetes was independently associated with all coronary parameters. CONCLUSION: Despite a significantly higher prevalence of obesity in diabetic subjects than in non-diabetic subjects, obesity is associated with the presence of any plaque and severe coronary calcification only in subjects without established diabetes among Korean population. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 134 | - |
dc.relation.isPartOf | DIABETOLOGY & METABOLIC SYNDROME | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Differential association between obesity and coronary artery disease according to the presence of diabetes in a Korean population | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | Yonsei Cardiovascular Research Institute (심혈관연구소) | - |
dc.contributor.googleauthor | Ki Bum Won | - |
dc.contributor.googleauthor | Hyuk Jae Chang | - |
dc.contributor.googleauthor | Hiroyuki Niinuma | - |
dc.contributor.googleauthor | Jimin Sung | - |
dc.contributor.googleauthor | In Jeong Cho | - |
dc.contributor.googleauthor | Chi Young Shim | - |
dc.contributor.googleauthor | Geu Ru Hong | - |
dc.contributor.googleauthor | Young Jin Kim | - |
dc.contributor.googleauthor | Byung Wook Choi | - |
dc.contributor.googleauthor | Namsik Chung | - |
dc.identifier.doi | 10.1186/1758-5996-6-134 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02213 | - |
dc.contributor.localId | A02429 | - |
dc.contributor.localId | A03490 | - |
dc.contributor.localId | A03585 | - |
dc.contributor.localId | A03892 | - |
dc.contributor.localId | A04059 | - |
dc.contributor.localId | A04386 | - |
dc.contributor.localId | A00727 | - |
dc.contributor.localId | A01955 | - |
dc.relation.journalcode | J00728 | - |
dc.identifier.eissn | 1758-5996 | - |
dc.identifier.pmid | 25530810 | - |
dc.subject.keyword | Cardiac computed tomographic angiography | - |
dc.subject.keyword | Coronary artery disease | - |
dc.subject.keyword | Diabetes | - |
dc.subject.keyword | Obesity | - |
dc.contributor.alternativeName | Kim, Young Jin | - |
dc.contributor.alternativeName | Sung, Ji Min | - |
dc.contributor.alternativeName | Shim, Chi Young | - |
dc.contributor.alternativeName | Won, Ki Bum | - |
dc.contributor.alternativeName | Chang, Hyuck Jae | - |
dc.contributor.alternativeName | Chung, Nam Sik | - |
dc.contributor.alternativeName | Cho, In Jeong | - |
dc.contributor.alternativeName | Choi, Byoung Wook | - |
dc.contributor.alternativeName | Hong, Geu Ru | - |
dc.contributor.affiliatedAuthor | Shim, Chi Young | - |
dc.contributor.affiliatedAuthor | Won, Ki Bum | - |
dc.contributor.affiliatedAuthor | Chang, Hyuck Jae | - |
dc.contributor.affiliatedAuthor | Chung, Nam Sik | - |
dc.contributor.affiliatedAuthor | Cho, In Jeong | - |
dc.contributor.affiliatedAuthor | Choi, Byoung Wook | - |
dc.contributor.affiliatedAuthor | Hong, Geu Ru | - |
dc.contributor.affiliatedAuthor | Kim, Young Jin | - |
dc.contributor.affiliatedAuthor | Sung, Ji Min | - |
dc.citation.volume | 6 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 134 | - |
dc.identifier.bibliographicCitation | DIABETOLOGY & METABOLIC SYNDROME, Vol.6(1) : 134, 2014 | - |
dc.identifier.rimsid | 45350 | - |
dc.type.rims | ART | - |
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