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Expression of sarcosine metabolism-related proteins according to metastatic site in breast cancer.

Authors
 Yoon Jin Cha  ;  Do Hee Kim  ;  Woo Hee Jung  ;  Ja Seung Koo 
Citation
 INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, Vol.7(11) : 7824-7833, 2014 
Journal Title
 INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 
Issue Date
2014
MeSH
Bone Neoplasms/metabolism ; Bone Neoplasms/secondary ; Brain Neoplasms/metabolism ; Brain Neoplasms/secondary ; Breast Neoplasms/metabolism* ; Breast Neoplasms/pathology ; Carcinoma, Ductal, Breast/metabolism* ; Carcinoma, Ductal, Breast/secondary ; Female ; Glycine N-Methyltransferase/metabolism* ; Humans ; Liver Neoplasms/metabolism ; Liver Neoplasms/secondary ; Lung Neoplasms/metabolism ; Lung Neoplasms/secondary ; Middle Aged ; Organ Specificity ; Sarcosine Dehydrogenase/metabolism* ; Sarcosine Oxidase/metabolism*
Keywords
Breast cancer ; metabolism ; molecular subtype ; sarcosine
Abstract
We aimed to evaluate the expression of sarcosine metabolism-related proteins according to site of metastatic breast cancer, and the clinical implications. Immunohistochemical staining for glycine N-methyltransferase (GNMT), sarcosine dehydrogenase (SARDH), and l-pipecolic acid oxidase (PIPOX) was performed on tissue microarrays from 162 metastatic breast cancer (bone metastases = 47, brain metastases = 39, liver metastases = 24, and lung metastases = 52). Sarcosine metabolism-related proteins showed variable expression with regard to metastatic sites. GNMT was expressed in brain and lung metastases, but not in bone and liver metastases (P = 0.016). In view of the sarcosine metabolic phenotype, high sarcosine and intermediate type were only found in the brain and lung metastases, and low sarcosine type was observed more frequently in bone and lung metastases (P = 0.047). By univariate analysis, PIPOX positivity was correlated with shorter overall survival (OS) (P = 0.031). In lung metastases, PIPOX positivity (P = 0.019) and stromal PIPOX positivity (P = 0.001) were associated with shorter OS. In conclusion, in metastatic breast cancer, sarcosine metabolism-related proteins are differently expressed according to the metastatic site. Expression of GNMT and high sarcosine type are predominantly observed in brain and lung metastases.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Koo, Ja Seung(구자승) ORCID logo https://orcid.org/0000-0003-4546-4709
Kim, Do Hee(김도희)
Jung, Woo Hee(정우희)
Cha, Yoon Jin(차윤진) ORCID logo https://orcid.org/0000-0002-5967-4064
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/138444
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