Cited 0 times in
Expression of sarcosine metabolism-related proteins according to metastatic site in breast cancer.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 구자승 | - |
dc.contributor.author | 김도희 | - |
dc.contributor.author | 정우희 | - |
dc.date.accessioned | 2015-12-28T10:59:03Z | - |
dc.date.available | 2015-12-28T10:59:03Z | - |
dc.date.issued | 2014 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/138444 | - |
dc.description.abstract | We aimed to evaluate the expression of sarcosine metabolism-related proteins according to site of metastatic breast cancer, and the clinical implications. Immunohistochemical staining for glycine N-methyltransferase (GNMT), sarcosine dehydrogenase (SARDH), and l-pipecolic acid oxidase (PIPOX) was performed on tissue microarrays from 162 metastatic breast cancer (bone metastases = 47, brain metastases = 39, liver metastases = 24, and lung metastases = 52). Sarcosine metabolism-related proteins showed variable expression with regard to metastatic sites. GNMT was expressed in brain and lung metastases, but not in bone and liver metastases (P = 0.016). In view of the sarcosine metabolic phenotype, high sarcosine and intermediate type were only found in the brain and lung metastases, and low sarcosine type was observed more frequently in bone and lung metastases (P = 0.047). By univariate analysis, PIPOX positivity was correlated with shorter overall survival (OS) (P = 0.031). In lung metastases, PIPOX positivity (P = 0.019) and stromal PIPOX positivity (P = 0.001) were associated with shorter OS. In conclusion, in metastatic breast cancer, sarcosine metabolism-related proteins are differently expressed according to the metastatic site. Expression of GNMT and high sarcosine type are predominantly observed in brain and lung metastases. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 7824~7833 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Bone Neoplasms/metabolism | - |
dc.subject.MESH | Bone Neoplasms/secondary | - |
dc.subject.MESH | Brain Neoplasms/metabolism | - |
dc.subject.MESH | Brain Neoplasms/secondary | - |
dc.subject.MESH | Breast Neoplasms/metabolism* | - |
dc.subject.MESH | Breast Neoplasms/pathology | - |
dc.subject.MESH | Carcinoma, Ductal, Breast/metabolism* | - |
dc.subject.MESH | Carcinoma, Ductal, Breast/secondary | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glycine N-Methyltransferase/metabolism* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Liver Neoplasms/metabolism | - |
dc.subject.MESH | Liver Neoplasms/secondary | - |
dc.subject.MESH | Lung Neoplasms/metabolism | - |
dc.subject.MESH | Lung Neoplasms/secondary | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Organ Specificity | - |
dc.subject.MESH | Sarcosine Dehydrogenase/metabolism* | - |
dc.subject.MESH | Sarcosine Oxidase/metabolism* | - |
dc.title | Expression of sarcosine metabolism-related proteins according to metastatic site in breast cancer. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Yoon Jin Cha | - |
dc.contributor.googleauthor | Do Hee Kim | - |
dc.contributor.googleauthor | Woo Hee Jung | - |
dc.contributor.googleauthor | Ja Seung Koo | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00395 | - |
dc.contributor.localId | A00198 | - |
dc.contributor.localId | A03671 | - |
dc.contributor.localId | A04001 | - |
dc.relation.journalcode | J01096 | - |
dc.identifier.eissn | 1936-2625 | - |
dc.identifier.pmid | 25550822 | - |
dc.subject.keyword | Breast cancer | - |
dc.subject.keyword | metabolism | - |
dc.subject.keyword | molecular subtype | - |
dc.subject.keyword | sarcosine | - |
dc.contributor.alternativeName | Koo, Ja Seung | - |
dc.contributor.alternativeName | Kim, Do Hee | - |
dc.contributor.alternativeName | Jung, Woo Hee | - |
dc.contributor.affiliatedAuthor | Kim, Do Hee | - |
dc.contributor.affiliatedAuthor | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | Jung, Woo Hee | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.citation.volume | 7 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 7824 | - |
dc.citation.endPage | 7833 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, Vol.7(11) : 7824-7833, 2014 | - |
dc.identifier.rimsid | 45314 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.