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Gender differences in the association between serum γ-glutamyltransferase and blood pressure change: a prospective community-based cohort study.

 Kyoung Hwa Ha  ;  Hyeon Chang Kim  ;  Sungha Park  ;  Sang Hyun Ihm  ;  Hae Young Lee 
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.29(10) : 1379-1384, 2014 
Journal Title
Issue Date
Adult ; Aged ; Alcohol Drinking ; Blood Pressure/genetics ; C-Reactive Protein/analysis ; Cohort Studies ; Female ; Humans ; Hypertension/enzymology* ; Hypertension/genetics ; Male ; Middle Aged ; Prospective Studies ; Risk Factors ; Sex Factors ; Triglycerides/blood ; gamma-Glutamyltransferase/blood* ; gamma-Glutamyltransferase/genetics
Blood Pressure ; Gender ; γ-Glutamyltransferase
We evaluated the gender differences in the relation of baseline serum γ-glutamyltransferase (GGT) levels to blood pressure (BP) change during 4 yr. 4,025 normotensive subjects (1,945 men and 2,080 women) who aged 40-69 yr at baseline participated in the Ansung-Ansan cohort of the Korean Genome Epidemiology Study were included. The associations of GGT with baseline BP or 4-yr change of BP were evaluated. GGT levels were associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) at baseline after adjusting for age, body mass index (BMI), HDL-cholesterol, triglyceride, C-reactive protein (CRP), current smoking status and alcohol intake (SBP, β=1.28, P<0.001; DBP, β=1.41, P<0.001). GGT levels were also associated with 4-yr change in BP after adjusting for age, BMI, HDL-cholesterol, triglyceride, CRP, current smoking status, alcohol intake and SBP (SBP, β=1.08, P=0.001; DBP, β=0.64, P=0.003). This association was statistically significant in men (SBP, β=1.82, P<0.001; DBP, β=1.05, P=0.001), but not in women (SBP, β=0.38, P=0.466; DBP, β=-0.37, P=0.304). Remarkably, this association between GGT and BP was significant in men at 40-49 yr of age. In summary, we found positive associations between GGT levels at baseline and the change of BP. The relation of GGT level and the change of BP was only significant in men, not in women, which warrants further studies to elucidate the biologic mechanisms.
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1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyeon Chang(김현창) ORCID logo https://orcid.org/0000-0001-7867-1240
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Ha, Kyoung Hwa(하경화)
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