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Cited 6 times in

Gender differences in the association between serum γ-glutamyltransferase and blood pressure change: a prospective community-based cohort study.

DC FieldValueLanguage
dc.contributor.author김현창-
dc.contributor.author박성하-
dc.contributor.author하경화-
dc.date.accessioned2015-12-28T10:58:45Z-
dc.date.available2015-12-28T10:58:45Z-
dc.date.issued2014-
dc.identifier.issn1011-8934-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/138433-
dc.description.abstractWe evaluated the gender differences in the relation of baseline serum γ-glutamyltransferase (GGT) levels to blood pressure (BP) change during 4 yr. 4,025 normotensive subjects (1,945 men and 2,080 women) who aged 40-69 yr at baseline participated in the Ansung-Ansan cohort of the Korean Genome Epidemiology Study were included. The associations of GGT with baseline BP or 4-yr change of BP were evaluated. GGT levels were associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) at baseline after adjusting for age, body mass index (BMI), HDL-cholesterol, triglyceride, C-reactive protein (CRP), current smoking status and alcohol intake (SBP, β=1.28, P<0.001; DBP, β=1.41, P<0.001). GGT levels were also associated with 4-yr change in BP after adjusting for age, BMI, HDL-cholesterol, triglyceride, CRP, current smoking status, alcohol intake and SBP (SBP, β=1.08, P=0.001; DBP, β=0.64, P=0.003). This association was statistically significant in men (SBP, β=1.82, P<0.001; DBP, β=1.05, P=0.001), but not in women (SBP, β=0.38, P=0.466; DBP, β=-0.37, P=0.304). Remarkably, this association between GGT and BP was significant in men at 40-49 yr of age. In summary, we found positive associations between GGT levels at baseline and the change of BP. The relation of GGT level and the change of BP was only significant in men, not in women, which warrants further studies to elucidate the biologic mechanisms.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1379~1384-
dc.relation.isPartOfJOURNAL OF KOREAN MEDICAL SCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAlcohol Drinking-
dc.subject.MESHBlood Pressure/genetics-
dc.subject.MESHC-Reactive Protein/analysis-
dc.subject.MESHCohort Studies-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHHypertension/enzymology*-
dc.subject.MESHHypertension/genetics-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHProspective Studies-
dc.subject.MESHRisk Factors-
dc.subject.MESHSex Factors-
dc.subject.MESHTriglycerides/blood-
dc.subject.MESHgamma-Glutamyltransferase/blood*-
dc.subject.MESHgamma-Glutamyltransferase/genetics-
dc.titleGender differences in the association between serum γ-glutamyltransferase and blood pressure change: a prospective community-based cohort study.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Preventive Medicine (예방의학)-
dc.contributor.googleauthorKyoung Hwa Ha-
dc.contributor.googleauthorHyeon Chang Kim-
dc.contributor.googleauthorSungha Park-
dc.contributor.googleauthorSang Hyun Ihm-
dc.contributor.googleauthorHae Young Lee-
dc.identifier.doi10.3346/jkms.2014.29.10.1379-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01142-
dc.contributor.localIdA01512-
dc.contributor.localIdA04246-
dc.relation.journalcodeJ01517-
dc.identifier.eissn1598-6357-
dc.identifier.pmid25368491-
dc.subject.keywordBlood Pressure-
dc.subject.keywordGender-
dc.subject.keywordγ-Glutamyltransferase-
dc.contributor.alternativeNameKim, Hyeon Chang-
dc.contributor.alternativeNamePark, Sung Ha-
dc.contributor.alternativeNameHa, Kyoung Hwa-
dc.contributor.affiliatedAuthorKim, Hyeon Chang-
dc.contributor.affiliatedAuthorPark, Sung Ha-
dc.contributor.affiliatedAuthorHa, Kyoung Hwa-
dc.citation.volume29-
dc.citation.number10-
dc.citation.startPage1379-
dc.citation.endPage1384-
dc.identifier.bibliographicCitationJOURNAL OF KOREAN MEDICAL SCIENCE, Vol.29(10) : 1379-1384, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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