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Urban-rural differences explain the association between serum 25-hydroxyvitamin D level and insulin resistance in Korea

 Bo Mi Song  ;  Yumie Rhee  ;  Chang Oh Kim  ;  Yoosik Youm  ;  Kyoung Min Kim  ;  Eun Young Lee  ;  Ju-Mi Lee  ;  Young Mi Yoon  ;  Hyeon Chang Kim 
 NUTRIENTS, Vol.6(12) : 5806-5818, 2014 
Journal Title
Issue Date
Aged ; Aged, 80 and over ; Asian Continental Ancestry Group ; Blood Glucose ; Body Mass Index ; Body Weight ; Cross-Sectional Studies ; Female ; Humans ; Insulin/blood ; Insulin Resistance* ; Linear Models ; Male ; Republic of Korea ; Rural Population* ; Surveys and Questionnaires ; Urban Population* ; Vitamin D/analogs & derivatives* ; Vitamin D/blood ; Waist Circumference
vitamin D ; insulin resistance ; elderly ; Korean ; residential area
An increasing number of studies report associations between low serum 25-hydroxyvitamin D [25(OH)D] level and insulin resistance; however, whether low vitamin D levels directly contribute to increased insulin resistance is unclear. We investigated the impact of residential area on the association between 25(OH)D and insulin resistance in elderly Koreans. Using data from the Korean Urban Rural Elderly study, we conducted cross-sectional analyses in 1628 participants (505 men and 1123 women). Serum 25(OH)D was analyzed as both continuous and categorized variables. Homeostasis model assessment for insulin resistance (HOMA-IR) was calculated using fasting blood glucose and insulin levels. In men, 25(OH)D level was inversely associated with HOMA-IR (standardized β = -0.133, p < 0.001) after adjustment for age, body mass index, waist circumference, smoking, alcohol intake, exercise, and study year. However, we noted significant urban-rural differences in 25(OH)D level (43.4 versus 65.6 nmol/L; p < 0.001) and HOMA-IR (1.2 versus 0.8 mmol · pmol/L2; p < 0.001). When we additionally adjusted for residential area, the association between 25(OH)D and HOMA-IR was attenuated (standardized β = -0.063, p = 0.115). In women, the association between 25(OH)D and HOMA-IR was not significant before or after adjustment for residential area. Environmental or lifestyle differences in urban and rural areas may largely explain the inverse association between serum 25(OH)D and insulin resistance.
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1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Oh(김창오) ORCID logo https://orcid.org/0000-0002-0773-5443
Kim, Hyeon Chang(김현창) ORCID logo https://orcid.org/0000-0001-7867-1240
Yun, Young Mi(윤영미)
Rhee, Yumie(이유미) ORCID logo https://orcid.org/0000-0003-4227-5638
Lee, Eun Young(이은영)
Lee, Ju Mi(이주미)
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