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Effects of 12 weeks of probiotic supplementation on quality of life in colorectal cancer survivors: a double-blind, randomized, placebo-controlled trial.

 Jee Yon Lee  ;  Sang Hui Chu  ;  Justin Y. Jeon  ;  Mi Kyung Lee  ;  Ji Hye Park  ;  Duk Chul Lee  ;  Ji Won Lee  ;  Nam Kyu Kim 
 DIGESTIVE AND LIVER DISEASE, Vol.46(12) : 1126-1132, 2014 
Journal Title
Issue Date
Adult ; Aged ; Aged, 80 and over ; Colorectal Neoplasms/complications* ; Double-Blind Method ; Female ; Humans ; Irritable Bowel Syndrome/etiology ; Irritable Bowel Syndrome/therapy* ; Male ; Middle Aged ; Probiotics/therapeutic use* ; Quality of Life* ; Survivors* ; Treatment Outcome
Bowel symptoms ; Cancer survivors ; Colorectal cancer ; Probiotics
BACKGROUND: Probiotics may help resolve bowel symptoms and improve quality of life. We investigated the effects of 12 weeks of probiotics administration in colorectal cancer patients. METHODS: We conducted a double-blind, randomized, placebo-controlled trial. The participants took probiotics (Lacidofil) or placebo twice a day for 12 weeks. The cancer-related quality of life (FACT), patient's health-9 (PHQ-9), and bowel symptom questionnaires were completed by each participant. RESULTS: We obtained data for 32 participants in the placebo group and 28 participants in the probiotics group. The mean ages of total participants were 56.18 ± .86 years and 58.3% were male. Administration of probiotics significantly decreased the proportion of patients suffering from irritable bowel symptoms (0 week vs. 12 week; 67.9% vs. 45.7%, p=0.03), improved colorectal cancer-related FACT (baseline vs. 12 weeks: 19.79 ± 4.66 vs. 21.18 ± 3.67, p=0.04) and fatigue-related FACT (baseline vs. 12 weeks: 43.00 (36.50-45.50) vs. 44.50 (38.50-49.00), p=0.02) and PHQ-9 scores (0 weeks vs. 12 weeks; 3.00 (0-8.00) vs. 1.00 (0-3.00), p=0.01). We found significant differences in changes of the proportion of patients with bowel symptoms (p<0.05), functional well-being scores (p=0.04) and cancer-related FACT scores (p=0.04) between the two groups. CONCLUSION: Probiotics improved bowel symptoms and quality of life in colorectal cancer survivors.
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
3. College of Nursing (간호대학) > Dept. of Nursing (간호학과) > 1. Journal Papers
Yonsei Authors
Kim, Nam Kyu(김남규) ORCID logo https://orcid.org/0000-0003-0639-5632
Lee, Duk Chul(이덕철) ORCID logo https://orcid.org/0000-0001-9166-1813
Lee, Jee Yon(이지연)
Lee, Ji Won(이지원) ORCID logo https://orcid.org/0000-0002-2666-4249
Chu, Sang Hui(추상희) ORCID logo https://orcid.org/0000-0001-6877-5599
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