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Protective role of gut commensal microbes against intestinal infections.

Authors
 My Young Yoon  ;  Keehoon Lee  ;  Sang Sun Yoon 
Citation
 JOURNAL OF MICROBIOLOGY, Vol.52(12) : 983-989, 2014 
Journal Title
 JOURNAL OF MICROBIOLOGY 
ISSN
 1225-8873 
Issue Date
2014
MeSH
Animals ; Bacteria/classification ; Bacteria/immunology ; Bacteria/metabolism ; Bacterial Infections/immunology* ; Gastrointestinal Tract/microbiology* ; Gastrointestinal Tract/physiopathology ; Homeostasis ; Humans ; Immunity, Innate ; Intestinal Diseases/immunology* ; Intestinal Diseases/microbiology* ; Microbiota* ; Symbiosis*/immunology ; Symbiosis*/physiology
Keywords
gut microbiota ; enteropathogenic bacterial infection ; colonization resistance
Abstract
The human gastrointestinal tract is colonized by multitudes of microorganisms that exert beneficial effects on human health. Mounting evidence suggests that intestinal microbiota contributes to host resistance against enteropathogenic bacterial infection. However, molecular details that account for such an important role has just begun to be understood. The commensal microbes in the intestine regulate gut homeostasis through activating the development of host innate immunity and producing molecules with antimicrobial activities that directly inhibit propagation of pathogenic bacteria. Understanding the protective roles of gut microbiota will provide a better insight into the molecular basis that underlies complicated interaction among host-pathogen-symbiont. In this review, we highlighted recent findings that help us broaden our knowledge of the intestinal ecosystem and thereby come up with a better strategy for combating enteropathogenic infection.
Full Text
http://link.springer.com/article/10.1007/s12275-014-4655-2
DOI
10.1007/s12275-014-4655-2
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Yoon, Mi Young(윤미영)
Yoon, Sang Sun(윤상선) ORCID logo https://orcid.org/0000-0003-2979-365X
Lee, Kee Hoon(이기훈)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/138282
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