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Synthesis and Anticancer Activity of Novel Deoxoartemisinin-Glycolipid Hybrids

Authors
 Dongguk Min  ;  Minkyu Kim  ;  Jérémy Ricci  ;  Sora Jung  ;  Kirim Kim  ;  Won Yoon Chung  ;  Kwang Kyun Park  ;  Mankil Jung 
Citation
 CHEMICAL & PHARMACEUTICAL BULLETIN, Vol.62(5) : 446-453, 2014 
Journal Title
 CHEMICAL & PHARMACEUTICAL BULLETIN 
ISSN
 0009-2363 
Issue Date
2014
MeSH
Antineoplastic Agents/chemical synthesis* ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology* ; Artemisinins/chemistry ; Artemisinins/pharmacology* ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Glycolipids/chemistry ; Glycolipids/pharmacology* ; Humans ; MCF-7 Cells ; Molecular Structure ; Structure-Activity Relationship
Keywords
anticancer activity ; oral squamous carcinoma ; deoxoartemisinin ; glycolipid hybrid
Abstract
The practical synthesis and anticancer activity of novel deoxoartemisinin-glycolipid hybrids, which incorporate two drugs into a single molecule and can impact multiple targets simultaneously are presented. These hybrids exhibited potent in vitro anticancer activity against several human cancer cell lines. The deoxoartemisinin-glycolipid hybrids generally demonstrated better anticancer activity than either artemisinin or daumone alone and cisplatin.
Files in This Item:
T201401442.pdf Download
DOI
10.1248/cpb.c14-00036
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ki Rim(김기림)
Park, Kwang Kyun(박광균)
Chung, Won Yoon(정원윤) ORCID logo https://orcid.org/0000-0001-8428-9005
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/138204
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