Synthesis and Anticancer Activity of Novel Deoxoartemisinin-Glycolipid Hybrids

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Authors: Dongguk Min ; Minkyu Kim ; Jérémy Ricci ; Sora Jung ; Kirim Kim ; Won Yoon Chung ; Kwang Kyun Park ; Mankil Jung

MeSH: Antineoplastic Agents/chemical synthesis* ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology* ; Artemisinins/chemistry ; Artemisinins/pharmacology* ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Glycolipids/chemistry ; Glycolipids/pharmacology* ; Humans ; MCF-7 Cells ; Molecular Structure ; Structure-Activity Relationship

Keywords: anticancer activity ; oral squamous carcinoma ; deoxoartemisinin ; glycolipid hybrid

Abstract: The practical synthesis and anticancer activity of novel deoxoartemisinin-glycolipid hybrids, which incorporate two drugs into a single molecule and can impact multiple targets simultaneously are presented. These hybrids exhibited potent in vitro anticancer activity against several human cancer cell lines. The deoxoartemisinin-glycolipid hybrids generally demonstrated better anticancer activity than either artemisinin or daumone alone and cisplatin.