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Pericardial fat volume is associated with clinical recurrence after catheter ablation for persistent atrial fibrillation, but not paroxysmal atrial fibrillation : an analysis of over 600-patients

Other Titles
 심막지방이 심방세동 전극도자 절제술의 임상적 결과에 미치는 영향 
 Dept. of Internal Medicine (내과학교실) 
Issue Date
Dept. of Medicine/석사
Background: Although pericardial fat volume (PFV) has been suggested to be associated with atrial fibrillation (AF), only a few studies have reported the association between pericardial fat and clinical outcome after radiofrequency catheter ablation (RFCA). The purpose of this study was to explore the factors associated with PFV and the prognostic significance of PFV after catheter ablation for AF, depending on the types of AF. Methods: We included 665 patients (76.7% male, 57.3±11.1 years of age, 67.7% with paroxysmal AF [PAF] and 32.3% with persistent AF [PeAF]) who underwent RFCA for AF, and compared PFV with clinical variables. The factors associated with clinical recurrence of AF were evaluated.Results: 1. On linear regression analysis, PFV (10cm3) was independently correlated with male gender (B=2.38, 95% CI 1.65-3.12, p<0.001), body mass index (B=0.59, 95% CI 0.48~0.69, p<0.001), and age (B=0.07, 95% CI 0.04~0.10, p<0.001). 2. During the 19.38.5 month follow-up period, the clinical recurrence rate was 26.5%. PFV (HR 1.06; 95% CI 1.02~1.10, p=0.004) and PeAF (HR 1.86; 95%CI 1.31~ 2.62, p<0.001) were independent predictors of clinical recurrence after RFCA. 3. PFV was significantly greater in PeAF patients with recurrence compared to those without (p=0.001), but, not in the PAF group (p=0.212). 4. PFV was independently associated with post-ablation recurrence only in PeAF (HR 1.10; 95%CI 1.05~1.16, p<0.001).Conclusions: PFV was independently associated with male gender, high body mass index, and old age, and a significant predictor for clinical recurrence of AF after catheter ablation for PeAF.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 2. Thesis
Yonsei Authors
Kim, Tae-Hoon(김태훈) ORCID logo https://orcid.org/0000-0003-4200-3456
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