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Histologic characteristics of small hepatocellular carcinomas showing atypical enhancement patterns on 4-phase multidetector CT examination

Issue Date
2012
Description
Dept. of Medicine/석사
Abstract
OBJECTIVE: The purpose of this study is to retrospectively define which histologic characteristics of small hepatocellular carcinomas (HCCs) are related to atypical dynamic enhancement on multi-detector computed tomography (MDCT) imaging.MATERIALS AND METHODS: Seventy-three patients with 83 HCCs (3cm or less in diameter) were included in this study. All patients underwent 4-phase MDCT imaging and subsequent surgery withineight weeks. Two independent radiologists blinded to the histologic findings retrospectively categorized the HCCs as either typical (showing increased enhancement on arterial phase images followed by washout in late phase images) or atypical lesions demonstrating any other enhancement pattern. From the original pathologic reports, various histologic characteristics including gross morphology, nuclear histologic grades, presence of capsule formation, and capsule infiltration if a capsule is present were compared between the two groups. RESULTS: Atypical enhancement pattern was seen in 30 (36.2%) of the 83 HCCs. The mean size of atypical HCCs (1.71 ± 0.764) was significantly smaller than that of typical HCCs (2.31 ± 0.598, p<0.001). Atypical HCCs were frequently found to be vaguely nodular in gross morphology (n=13, 43.3%) and to have grade I nuclear grades (n=17, 56.7%). Capsule formation was significantly more common in typical HCCs (p<0.001). Capsular infiltration was also more common in typical HCCs (p=0.001).CONCLUSION: HCCs showing atypical dynamic enhancement on MDCT imaging are usually smaller than typical HCCs, mostly of the vaguely nodular type in gross morphology, well-differentiated in nuclear grades, and lack capsule formation or capsular infiltration.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/134201
Appears in Collections:
2. 학위논문 > 1. College of Medicine (의과대학) > 석사
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