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Usefulness of gadobenate dimeglumine-enhanced hepatobiliary phase MR imaging on predicting histological grade of hepatocellular carcinoma

Other Titles
 Gadobenate Dimeglumine 조영증강 간담도기 자기공명영상을 이용한 간세포암의 병리학적 분화도 예측 
Authors
 박성호 
Issue Date
2012
Description
Dept. of Medicine/석사
Abstract
Purpose : To assess the usefulness of gadobenate dimeglumine-enhanced hepatobiliary phase MR imaging for evaluation of histological characteristics of hepatocellular carcinoma (HCC).Materials and Methods : 57 HCCs histopathologically proved by surgery in 51 patients were retrospectively evaluated. All patients underwent gadobenate dimeglumine-enhanced MR imaging prior to surgery. The signal-to-noise ratio (SNR) of lesion and liver, and the liver-to-lesion contrast-to-noise ratio (CNR) for both pre- and postcontrast hepatobiliary phase were measured and contrast enhancement ratio (CER) of lesion and liver were calculated to correlate with three groups stratified by histological grades (Edmondson-Steiner classification) of the lesions. The differences between means of each group were statistically analyzed with one-way analysis of variance test. Results : The liver-to-lesion CNRs of well-differentiated HCCs (n=9) on pre- (-0.8±13.2) and postcontrast hepatobiliary phase images (13.2±30.4) were significantly lower (P<0.05) compared to those of moderately (14.2±9.4 and 39.1±15.4 on pre- and postcontrast, respectively) (n=37) and poorly differentiated HCCs (18.6±11.3 and 39.3±27.9) (n=11), respectively. There were no significant difference for CERs between three histological tumor grades. Conclusion : Gadobenate dimeglumine-enhanced hepatobiliary phase MR imaging can help predict the histological grades of hepatocellular carcinomas preoperatively, especially differentiating well- from moderately and poorly differentiated HCCs.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/133757
Appears in Collections:
2. Thesis / Dissertation (학위논문) > 1. College of Medicine (의과대학) > Master's Degree (석사)
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