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Usefulness of gadobenate dimeglumine-enhanced hepatobiliary phase MR imaging on predicting histological grade of hepatocellular carcinoma
DC Field | Value | Language |
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dc.contributor.author | 박성호 | - |
dc.date.accessioned | 2015-12-24T08:35:23Z | - |
dc.date.available | 2015-12-24T08:35:23Z | - |
dc.date.issued | 2012 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/133757 | - |
dc.description | Dept. of Medicine/석사 | - |
dc.description.abstract | Purpose : To assess the usefulness of gadobenate dimeglumine-enhanced hepatobiliary phase MR imaging for evaluation of histological characteristics of hepatocellular carcinoma (HCC).Materials and Methods : 57 HCCs histopathologically proved by surgery in 51 patients were retrospectively evaluated. All patients underwent gadobenate dimeglumine-enhanced MR imaging prior to surgery. The signal-to-noise ratio (SNR) of lesion and liver, and the liver-to-lesion contrast-to-noise ratio (CNR) for both pre- and postcontrast hepatobiliary phase were measured and contrast enhancement ratio (CER) of lesion and liver were calculated to correlate with three groups stratified by histological grades (Edmondson-Steiner classification) of the lesions. The differences between means of each group were statistically analyzed with one-way analysis of variance test. Results : The liver-to-lesion CNRs of well-differentiated HCCs (n=9) on pre- (-0.8±13.2) and postcontrast hepatobiliary phase images (13.2±30.4) were significantly lower (P<0.05) compared to those of moderately (14.2±9.4 and 39.1±15.4 on pre- and postcontrast, respectively) (n=37) and poorly differentiated HCCs (18.6±11.3 and 39.3±27.9) (n=11), respectively. There were no significant difference for CERs between three histological tumor grades. Conclusion : Gadobenate dimeglumine-enhanced hepatobiliary phase MR imaging can help predict the histological grades of hepatocellular carcinomas preoperatively, especially differentiating well- from moderately and poorly differentiated HCCs. | - |
dc.description.statementOfResponsibility | open | - |
dc.publisher | Graduate School, Yonsei University | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Usefulness of gadobenate dimeglumine-enhanced hepatobiliary phase MR imaging on predicting histological grade of hepatocellular carcinoma | - |
dc.title.alternative | Gadobenate Dimeglumine 조영증강 간담도기 자기공명영상을 이용한 간세포암의 병리학적 분화도 예측 | - |
dc.type | Thesis | - |
dc.contributor.alternativeName | Park, Sung Ho | - |
dc.type.local | Thesis | - |
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