人蔘이 胃酸度에 미치는 影響

Abstract

[한글]

[영문]

Panax Ginseng, a Korean herb medicine has been used widely in various conditions such as general weakness, anemia, postpartum weakness, neurasthenia, easy fatigability, diabetes, and gastro intestinal disorders especially stomach troubles.

Lee et al (1960) reported the histamine-liberating action of Ginseng, and Hwang (1960) showed that ethanol extract of Ginseng produced gastric hemorrhage with changes in gastric acidity. Sorokhtin (1955) reported that Ginseng was effective in alleviating the symptoms of chronic gastritis irrespective of gastric acidity, and according to the study carried by Yoon (1960), the ethanol extract of Panax Ginseng could decrease histamine stimulated gastric acidity in the dogs.

These studies suggested that Ginseng has some effects on gastric acidity, and so, this sis a report attempted to clarify the gastric stimulating effect of Ginseng in man.

Studies was made on 4 patients with hypoacidity, 8 patients with normoacidity, and 18 patients with hyperacidity, who were admitted to the Severance Hospital, Yonsei University College of Medicine from August, 1967 to November, 1967.

One hundred ml. of Ginseng water extract containing 20 gm. of Ginseng was used in this study. Each patient had two gastric juice analyses, the first after ingestion of Ewald test meal, and the second following Ginseng extract. And the results were compared.

The pH of Ginseng water extract was 5.72±0.3.

There was no appreciable difference between the result of gastric acidity stimulated by Ginseng extract and that following an Ewald test meal in patients with hypoacidity.

In the patients with normoacidity, gastric acidity was increased by 18.2 clinical units following ginseng extract, as compared with the results of the Ewald test meal.

And in the patients with hyperacidity, 11.4 clinical units of gastric acidity was increased by Ginseng extract over the Ewald test meal.

The over-all acidity after ingestion of Ginseng extract was 10.6 clinical units higher than that following Ewald test meal.

The increments of gastric acidity stimulated by Ginseng extract were more prominent in normal patients, and less in the patients with peptic ulcer. According to gastric diseases, the over-all acidity increments following Ginseng extract were in the following order; normal (15.6 C.U.), gastritis (9.6 C.U.), and peptic ulcer (8.8 C.U.).

With the results of this study, it may be concluded that Ginseng can stimulate the gastric acid secretion in man, but it can't be concluded that Ginseng induces ulceration and/or aggravation of peptic ulcer because of the numerous other factors

involved.