원발성 간암에서의 Alpha₁- Fetoprotein 양성군과 음성군간의 임상적 및 병리조직학적 소견의 차이에 대한 연구

Abstract

[한글]

The Differences in Clinical and Pathological Findings between Alpha-l-Fetoprotein

Positive and Negative Groups of the Hepatoma

Seung Yun Cho

Department of Medical Science The Graduate School Yonsei University

(Directed by Prof. Heung Jai Choi)

Although alph-l-fetoprotein(AFP), a normal alpha-l-globulin during fetal life,

has been proven to be of value in the diagnosis of hepatoma, little is known about

the differences in clinical and pathological findings between AFP positive and

negative groups of the hepatoma.

Sera from 191 patients with the diagnosis of hepatoma were tested for the

presence of AFP using an Micro-Ouchterlony double immunodiffusion technique. We

correlated the presence of AFP with the clinical and pathological features.

The following results were obtained:

1. Serum AFP was positive in 117 out of 191 patients with hepatome (61.6%). Among

the 191 patients with hepatoma, the diagnosis was confirmed pathologically in 76

and was made clinically in 115. In 45 out of 76 pathologically confirmed cases

(59.2%), and in 72 out of 115 clinically diagnosed cases (62.6%), the serum AFP was

positive.

2. The male to female ratio of patients with hepatoma was 5.2:1. A greater

percentage of female patients with hepatoma than male patients had AFP positive

serum(67.7% versus 60.0%), but this difference was statistically not

significant(P>0.10).

3. The majority of the patients with hepatoma was in 5th and 6 th decades. The

fact that serum AFP appeared more frequently in younger patients and less

frequently in older patients has been observed.

4. the occurrence of AFP was highly frequent in patients with metastatic

hepatoma(91.7%).

5. Those patients with AFP positive hepatoma had a higher serum total cholesterol

than patients with AFP negative hepatoma(246±18 mg% versus 183±11 mg%, P<0.01).

However, there was no close relationship between the presence of AFP in the serum

and any other clinical feature or biochemaical tests, such as the duration of

symptoms, liver size, serum bilirubin, and alkaline phosphatase levels.

6. Patients with poorly differentiated hepatoma and with hepatoma with basohpilic

cytoplasm tended to be AFP positive.

7. There was a higher AFP occurrence in patients with hepatoma associated with

cirrhosis than in those without cirrhosis(64.3% versus 47.3%), but this difference

was statistically not significant(P>0.10).

[영문]

Although alph-l-fetoprotein(AFP), a normal alpha-l-globulin during fetal life, has been proven to be of value in the diagnosis of hepatoma, little is known about the differences in clinical and pathological findings between AFP positive and

negative groups of the hepatoma.

Sera from 191 patients with the diagnosis of hepatoma were tested for the presence of AFP using an Micro-Ouchterlony double immunodiffusion technique. We correlated the presence of AFP with the clinical and pathological features.

The following results were obtained:

1. Serum AFP was positive in 117 out of 191 patients with hepatome (61.6%). Among the 191 patients with hepatoma, the diagnosis was confirmed pathologically in 76 and was made clinically in 115. In 45 out of 76 pathologically confirmed cases

(59.2%), and in 72 out of 115 clinically diagnosed cases (62.6%), the serum AFP was positive.

2. The male to female ratio of patients with hepatoma was 5.2:1. A greater percentage of female patients with hepatoma than male patients had AFP positive serum(67.7% versus 60.0%), but this difference was statistically not significant(P>0.10).

3. The majority of the patients with hepatoma was in 5th and 6 th decades. The fact that serum AFP appeared more frequently in younger patients and less frequently in older patients has been observed.

4. the occurrence of AFP was highly frequent in patients with metastatic hepatoma(91.7%).

5. Those patients with AFP positive hepatoma had a higher serum total cholesterol than patients with AFP negative hepatoma(246±18 mg% versus 183±11 mg%, P<0.01).

However, there was no close relationship between the presence of AFP in the serum and any other clinical feature or biochemaical tests, such as the duration of symptoms, liver size, serum bilirubin, and alkaline phosphatase levels.

6. Patients with poorly differentiated hepatoma and with hepatoma with basohpilic cytoplasm tended to be AFP positive.

7. There was a higher AFP occurrence in patients with hepatoma associated with cirrhosis than in those without cirrhosis(64.3% versus 47.3%), but this difference was statistically not significant(P>0.10).