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간문맥종양혈전증을 동반한 간세포암종에서 반복적인 간동맥 내 항암약물주입요법의 효과

Other Titles
 Efficacy of Repeated Hepatic Arterial Infusion Chemotherapy in Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis 
 안상훈  ;  심명기  ;  한광협  ;  이도연  ;  원종윤  ;  문영명  ;  전재윤  ;  김성애  ;  김자경  ;  박준용  ;  김도영 
 Korean Journal of Hepatology (대한간학회지), Vol.11(3) : 268-274, 2005 
Journal Title
Korean Journal of Hepatology(대한간학회지)
Issue Date
Hapatocellular carcinoma ; Portal vein ; Thrombosis ; Intraarterial infusion
Hapatocellular carcinoma ; Portal vein ; Thrombosis ; Intraarterial infusion
Background/Aims: The aim of this study is to elucidate the efficacy of repeated hepatic arterial infusion chemotherapy (HAIC) and different chemotherapeutic regimens for treating patients having advanced hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT).
Methods: From Jan. 1999 and Dec. 2003, a total of 103 patients diagnosed as having HCC with PVTT, but without extrahepatic spreading, were enrolled in this study. They were stratified into two groups. Group I (67 patients) received intraarterial cisplatin (CDDP, 80㎎/㎡ for 2 hours on Day 1), Group Ⅱ (36 patients) received intraarterial CDDP (6080㎎/㎡ for 2 hours on Day 2) and 5-fluorouracil (5-FU, 50080㎎/㎡ for 5 hours on Day 1-3). They were scheduled to receive at least three consecutive courses of the HAIC at 1 month intervals.
Results: Among the 66 patients who completed the protocol, one (2.5%) and seven (17.5%) patients of group Ⅰ, and one (3.8%) and four (15.4%) of group Ⅱ, exhibited complete and partial responses, respectively. The median survival period of all the patients was 6 months. Group Ⅱ showed a tendency to improve the median survival compared to group Ⅰ (8.5 vs 5.0 months, respectively, P=0.45). The most common adverse reaction was nausea (58.2%). However, an elevation of the total bilirubin level was more frequent in Group Ⅰ than in Group Ⅱ (61.3% vs 20.7%, respectively, P<0.05).
Conclusions: Repeated HAIC using CDDP achieved favorable results in a few patients with HCC with PVTT, and additional 5-FU may be useful. (Korean J Hepatol 2005;11:268-274)
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Do Young(김도영)
Kim, Sung Ai(김성애)
Kim, Ja Kyung(김자경) ORCID logo https://orcid.org/0000-0001-5025-6846
Sim, Myoung Ki(심명기)
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Won, Jong Yun(원종윤) ORCID logo https://orcid.org/0000-0002-8237-5628
Lee, Do Yun(이도연)
Chon, Chae Yoon(전재윤)
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
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