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기계적 자극이 치주인대 세포의 osteoprotegerin과 receptor activator of nuclear factor κB ligand mRNA 발현에 미치는 영향

Other Titles
 The effect of progressive tensional force on mRNA expression of osteoprotegerin and receptor activator of nuclear factor κB ligand in the human periodontal ligament cell 
Authors
 이기주  ;  이승일  ;  전옥순  ;  옥승호  ;  황충주 
Citation
 KOREAN JOURNAL OF ORTHODONTICS, Vol.35(4) : 262-274, 2005 
Journal Title
KOREAN JOURNAL OF ORTHODONTICS(대한치과교정학회지)
ISSN
 2234-7518 
Issue Date
2005
MeSH
Mechanical strain ; Periodontal ligament cell ; Osteoprotegerin ; Receptor activator of nuclear factor kB ligand
Keywords
Mechanical strain ; Periodontal ligament cell ; Osteoprotegerin ; Receptor activator of nuclear factor kB ligand
Abstract
Tooth movement is a result of mutual physiologic responses between the periodontal ligament and alveolar bone stimulated by mechanical strain. The PDL cell and osteoblast are known to have an influence on bone formation by controlling collagen synthesis and alkaline phosphatase activation. Moreover, recent studies have shown that the PDL cell and osteoblast release osteoprotegerin(OPG) and the receptor activator of nuclear factor κB ligand (RANKL) to control the level of osteoclast differentiation and activation which in turn influences bone resorption. In this study, progressively increased, continuous tenslonal force was applied to PDL cells. The objective was to progressively increased. continuous tensional force was applied to PDL cells. The objective was to find out which kind of biochemical reactions occur after tensional force application and to illuminate the alveolar bone resorption and apposition mechanism. Continuous and progressively increased tensile force was applied to PDL cells cultured on a petriperm dish wlth a flexible membrane. The amount of PGE_(2) and ALP synthesis were measured after 1, 3, 6 and 12 hours of force application. Secondly, RT-PCR analysis was carried out for OPG and RANKL whlch control osteoclast differentiation and MMP-1, -8, -9, -13 and TIMP-1 which regulate the resolution of collagen and resorption of the osteoid layer. According to the results, we concluded that progressively increased, continuous force application to human PDL cells reduces PGE_(2) synthesls, and increases OPG mRNA expression.
Files in This Item:
T200502911.pdf Download
DOI
OAK-2005-02052
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Orthodontics (교정과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Syng Ill(이승일)
Hwang, Chung Ju(황충주) ORCID logo https://orcid.org/0000-0003-3024-4551
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/114869
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