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A beneficial effect of simvastatin on DNA damage in 242T allele of the NADPH oxidase p22phox in hypercholesterolemic patients

Authors
 Min-Jeong Shin  ;  Eun Young Cho  ;  Namsik Chung  ;  Hyun Young Park  ;  Sung-Soon Kim  ;  Young-Guk Ko  ;  Jong-Won Ha  ;  Seok-Min Kang  ;  Se-Joong Rim  ;  Seung-Yun Cho  ;  Won-Heum Shim  ;  Jong Ho Lee  ;  Yangsoo Jang 
Citation
 Clinica Chimica Acta, Vol.360(1-2) : 46-51, 2005 
Journal Title
 Clinica Chimica Acta 
ISSN
 0009-8981 
Issue Date
2005
Abstract
BACKGROUND: The effect of simvastatin on DNA damage in hypercholesterolemic patients was investigated, and the relationship between the C242T polymorphism of the NADPH oxidase p22phox gene and the antioxidant effects of simvastatin was examined. METHODS: Simvastatin (20-40 mg /day) was administered for 8 weeks in 72 hypercholesterolemic patients. DNA damage in lymphocytes was quantified using single-cell gel electrophoresis (COMET assay) by measuring tail DNA (%), tail length (microm) and tail moment (tail length x % tail DNA/100). RESULTS: Simvastatin significantly reduced DNA damage as expressed by tail DNA (%, p< 0.001), tail length (mum, p<0.001) and tail moment on the DNA in lymphocytes (p<0.001) after 8 weeks. The frequencies of the C242T genotypes for CC, TC, and TT were 75.0%, 23.6% and 1.4% in the subjects. In the presence of the 242T allele, there were higher levels of baseline DNA damage and also a greater improvement in the DNA damage after 8 week simvastatin treatment compared with the CC homozygotes. CONCLUSION: Simvastatin significantly reduced DNA damage of hypercholesterolemic patients. This study showed that simvastatin has a beneficial effect on the improvement of DNA damage in patients with the 242T allele of NADPH oxidase p22phox gene.
Full Text
http://www.sciencedirect.com/science/article/pii/S0009898105002457
DOI
10.1016/j.cccn.2005.04.001
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
강석민(Kang, Seok Min) ORCID logo https://orcid.org/0000-0001-9856-9227
고영국(Ko, Young Guk) ORCID logo https://orcid.org/0000-0001-7748-5788
김성순(Kim, Sung Soon)
심원흠(Shim, Won Heum)
임세중(Rim, Se Joong) ORCID logo https://orcid.org/0000-0002-7631-5581
장양수(Jang, Yang Soo) ORCID logo https://orcid.org/0000-0002-2169-3112
정남식(Chung, Nam Sik)
조승연(Cho, Seung Yun)
하종원(Ha, Jong Won) ORCID logo https://orcid.org/0000-0002-8260-2958
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/114796
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