Cited 13 times in
A beneficial effect of simvastatin on DNA damage in 242T allele of the NADPH oxidase p22phox in hypercholesterolemic patients
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 장양수 | - |
dc.contributor.author | 정남식 | - |
dc.contributor.author | 조승연 | - |
dc.contributor.author | 하종원 | - |
dc.contributor.author | 강석민 | - |
dc.contributor.author | 고영국 | - |
dc.contributor.author | 김성순 | - |
dc.contributor.author | 심원흠 | - |
dc.contributor.author | 임세중 | - |
dc.date.accessioned | 2015-08-26T16:37:02Z | - |
dc.date.available | 2015-08-26T16:37:02Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0009-8981 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/114796 | - |
dc.description.abstract | BACKGROUND: The effect of simvastatin on DNA damage in hypercholesterolemic patients was investigated, and the relationship between the C242T polymorphism of the NADPH oxidase p22phox gene and the antioxidant effects of simvastatin was examined. METHODS: Simvastatin (20-40 mg /day) was administered for 8 weeks in 72 hypercholesterolemic patients. DNA damage in lymphocytes was quantified using single-cell gel electrophoresis (COMET assay) by measuring tail DNA (%), tail length (microm) and tail moment (tail length x % tail DNA/100). RESULTS: Simvastatin significantly reduced DNA damage as expressed by tail DNA (%, p< 0.001), tail length (mum, p<0.001) and tail moment on the DNA in lymphocytes (p<0.001) after 8 weeks. The frequencies of the C242T genotypes for CC, TC, and TT were 75.0%, 23.6% and 1.4% in the subjects. In the presence of the 242T allele, there were higher levels of baseline DNA damage and also a greater improvement in the DNA damage after 8 week simvastatin treatment compared with the CC homozygotes. CONCLUSION: Simvastatin significantly reduced DNA damage of hypercholesterolemic patients. This study showed that simvastatin has a beneficial effect on the improvement of DNA damage in patients with the 242T allele of NADPH oxidase p22phox gene. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 46~51 | - |
dc.relation.isPartOf | CLINICA CHIMICA ACTA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Alleles | - |
dc.subject.MESH | Anticholesteremic Agents/administration & dosage | - |
dc.subject.MESH | Anticholesteremic Agents/pharmacology | - |
dc.subject.MESH | Comet Assay | - |
dc.subject.MESH | DNA Damage/drug effects* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Frequency | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypercholesterolemia/drug therapy* | - |
dc.subject.MESH | Hypercholesterolemia/genetics* | - |
dc.subject.MESH | Lymphocytes | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Membrane Transport Proteins/genetics* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | NADPH Oxidases/genetics* | - |
dc.subject.MESH | Oxidation-Reduction | - |
dc.subject.MESH | Phosphoproteins/genetics* | - |
dc.subject.MESH | Polymorphism, Single Nucleotide | - |
dc.subject.MESH | Simvastatin/administration & dosage | - |
dc.subject.MESH | Simvastatin/pharmacology* | - |
dc.title | A beneficial effect of simvastatin on DNA damage in 242T allele of the NADPH oxidase p22phox in hypercholesterolemic patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Min-Jeong Shin | - |
dc.contributor.googleauthor | Eun Young Cho | - |
dc.contributor.googleauthor | Namsik Chung | - |
dc.contributor.googleauthor | Hyun Young Park | - |
dc.contributor.googleauthor | Sung-Soon Kim | - |
dc.contributor.googleauthor | Young-Guk Ko | - |
dc.contributor.googleauthor | Jong-Won Ha | - |
dc.contributor.googleauthor | Seok-Min Kang | - |
dc.contributor.googleauthor | Se-Joong Rim | - |
dc.contributor.googleauthor | Seung-Yun Cho | - |
dc.contributor.googleauthor | Won-Heum Shim | - |
dc.contributor.googleauthor | Jong Ho Lee | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.identifier.doi | 10.1016/j.cccn.2005.04.001 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03448 | - |
dc.contributor.localId | A03585 | - |
dc.contributor.localId | A03844 | - |
dc.contributor.localId | A04257 | - |
dc.contributor.localId | A00037 | - |
dc.contributor.localId | A00127 | - |
dc.contributor.localId | A00573 | - |
dc.contributor.localId | A02202 | - |
dc.contributor.localId | A03372 | - |
dc.relation.journalcode | J00543 | - |
dc.identifier.eissn | 1873-3492 | - |
dc.identifier.pmid | 15936011 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0009898105002457 | - |
dc.subject.keyword | NADPH oxidase | - |
dc.subject.keyword | Polymorphism | - |
dc.subject.keyword | DNA damage | - |
dc.subject.keyword | Simvastatin | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.alternativeName | Chung, Nam Sik | - |
dc.contributor.alternativeName | Cho, Seung Yun | - |
dc.contributor.alternativeName | Ha, Jong Won | - |
dc.contributor.alternativeName | Kang, Seok Min | - |
dc.contributor.alternativeName | Ko, Young Guk | - |
dc.contributor.alternativeName | Kim, Sung Soon | - |
dc.contributor.alternativeName | Shim, Won Heum | - |
dc.contributor.alternativeName | Rim, Se Joong | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Chung, Nam Sik | - |
dc.contributor.affiliatedAuthor | Cho, Seung Yun | - |
dc.contributor.affiliatedAuthor | Ha, Jong Won | - |
dc.contributor.affiliatedAuthor | Kang, Seok Min | - |
dc.contributor.affiliatedAuthor | Ko, Young Guk | - |
dc.contributor.affiliatedAuthor | Kim, Sung Soon | - |
dc.contributor.affiliatedAuthor | Shim, Won Heum | - |
dc.contributor.affiliatedAuthor | Rim, Se Joong | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 360 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 46 | - |
dc.citation.endPage | 51 | - |
dc.identifier.bibliographicCitation | CLINICA CHIMICA ACTA, Vol.360(1-2) : 46-51, 2005 | - |
dc.identifier.rimsid | 38480 | - |
dc.type.rims | ART | - |
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