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Diffusion-tensor MR imaging and fiber tractography: A new method of describing aberrant fiber connections in developmental CNS anomalies

Authors
 Seung-Koo Lee  ;  Dong Ik Kim  ;  Susumu Mori  ;  Dong Seok Kim  ;  Heung Dong Kim  ;  Dong Joon Kim  ;  Jinna Kim 
Citation
 RADIOGRAPHICS, Vol.25(1) : 53-65, 2005 
Journal Title
 RADIOGRAPHICS 
ISSN
 0271-5333 
Issue Date
2005
MeSH
Adolescent ; Adult ; Brain/abnormalities* ; Brain/pathology* ; Child ; Diffusion Magnetic Resonance Imaging* ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Nerve Fibers/pathology
Keywords
15653586
Abstract
Congenital anomalies of the central nervous system (CNS) often demonstrate aberrant white matter connections, which may be better characterized with diffusion-tensor imaging (DTI) and fiber tractography (FT) than with conventional magnetic resonance (MR) imaging. DTI-FT demonstrates abnormal hemispheric fiber connections in callosal agenesis or acquired disease of the corpus callosum. Decreased anisotropy of white matter adjacent to the malformed cortex and an aberrant course of major fiber pathways due to dysplastic white matter are common findings in cortical dysplasia. Increased anisotropy of dysplastic gray matter in heterotopia supports the hypothesis that developing neurons migrate from the ependyma to the cortex with a radial growth pattern. In periventricular leukomalacia, DTI-FT demonstrates an intact corticospinal tract and decreased thalamocortical sensory connections, which are responsible for the spasticity of cerebral palsy owing to impairment of inhibitory function. Joubert syndrome comprises malformation of the cerebellar vermis and an aberrant connection between the cerebellum and the cerebral cortex via an elongated and abnormally shaped superior cerebellar peduncle, which are well visualized with DTI-FT. In developmental CNS disease, DTI-FT demonstrates additional findings beyond those seen with conventional MR imaging. Future studies will focus on determining the significance of the aberrant fiber connections and their relationships to the clinical manifestations of CNS anomalies.
Full Text
http://pubs.rsna.org/doi/abs/10.1148/rg.251045085
DOI
10.1148/rg.251045085
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Seok(김동석)
Kim, Dong Ik(김동익)
Kim, Dong Joon(김동준) ORCID logo https://orcid.org/0000-0002-7035-087X
Kim, Jinna(김진아) ORCID logo https://orcid.org/0000-0002-9978-4356
Lee, Seung Koo(이승구) ORCID logo https://orcid.org/0000-0001-5646-4072
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/114767
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