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Surface modulation of magnetic nanocrystals in the development of highly efficient magnetic resonance probes for intracellular labeling

Authors
 Ho-Taek Song  ;  Jin-sil Choi  ;  Jinwoo Cheon  ;  Jin-Suck Suh  ;  Young-wook Jun  ;  Sungjun Kim  ;  Yong-Min Huh 
Citation
 Journal of the American Chemical Socierty, Vol.127(28) : 9992-9993, 2005 
Journal Title
 Journal of the American Chemical Socierty 
ISSN
 0002-7863 
Issue Date
2005
MeSH
Cell Line, Tumor ; Crystallization ; Ferric Compounds/chemistry* ; Humans ; Ligands ; Magnetic Resonance Spectroscopy* ; Magnetics* ; Molecular Probes* ; Nanostructures/chemistry* ; Solubility ; Surface Properties ; Water/chemistry
Keywords
16011350
Abstract
High-quality biocompatible magnetic iron oxide (Fe3O4) nanocrystals were developed through a ligand exchange process of hydrophobically capped nanocrystals with hydrophilic molecules. By simple modulation of the nanocrystal surface ligand charge properties, we have been able to prepare magnetic nanocrystals with excellent intracellular labeling capabilities that efficiently label a variety of cell types without the need for additional transport facilitating agents. The excellent intracellular labeling capability of the newly developed cationic WSIO has further led to successful MRI monitoring of the migration of neural stem cells in rat spinal cord. The magnetic nanocrystals developed here have great potential in applications for labeling of various cell types and also the monitoring of cell-based medical treatments and cancer metastasis.
Full Text
http://pubs.acs.org/doi/abs/10.1021/ja051833y
DOI
10.1021/ja051833y
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Song, Ho Taek(송호택) ORCID logo https://orcid.org/0000-0002-6655-2575
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/114765
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