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Evidence from the stop-EGFP mouse supports a niche-sharing model of epidermal proliferative units

Authors
 Simon Ro  ;  Bruce Rannala 
Citation
 Experimental Dermatology, Vol.14(11) : 838-843, 2005 
Journal Title
 Experimental Dermatology 
ISSN
 0906-6705 
Issue Date
2005
Abstract
The classical model of epidermal proliferative units (EPUs) postulates that each EPU is composed of a single column of corneocytes plus epidermal cells directly below the column and is maintained by a single stem cell within the unit. Using the stop-enhanced green fluorescent protein (stop-EGFP) transgenic mouse system, we previously showed epidermal stem cell clonal lineages could produce multiple adjacent corneocytes (i.e. epidermal cells belonging to multiple adjacent EPUs), contradicting the classical EPU model. One possible problem with our earlier study was that N-ethyl-N-nitrosourea (ENU) was used to generate mutations for clonal analysis. This could alter the normal environment of the epidermal tissue and might lead to an artificial expansion of stem cell clonal lineages. In this study, we replicate our earlier findings using untreated stop-EGFP mice and relying on spontaneous mutations to generate clonal cell lineages. We propose an alternative to the classical EPU model to explain the dynamic nature of epidermal proliferation. Our niche-sharing model of EPUs allows epidermal cells to horizontally migrate among EPUs, so that multiple stem cells cooperatively maintain a larger proliferative compartment.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0625.2005.00366.x/abstract
DOI
10.1111/j.1600-0625.2005.00366.x
Appears in Collections:
5. Research Institutes (연구소) > Liver Cirrhosis Clinical Research Center (간경변증임상연구센터) > 1. Journal Papers
Yonsei Authors
노원상(Ro, Simon Weonsang) ORCID logo https://orcid.org/0000-0003-2187-3698
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/114757
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