Cited 25 times in
Evidence from the stop-EGFP mouse supports a niche-sharing model of epidermal proliferative units
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 노원상 | - |
dc.date.accessioned | 2015-08-26T16:35:37Z | - |
dc.date.available | 2015-08-26T16:35:37Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0906-6705 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/114757 | - |
dc.description.abstract | The classical model of epidermal proliferative units (EPUs) postulates that each EPU is composed of a single column of corneocytes plus epidermal cells directly below the column and is maintained by a single stem cell within the unit. Using the stop-enhanced green fluorescent protein (stop-EGFP) transgenic mouse system, we previously showed epidermal stem cell clonal lineages could produce multiple adjacent corneocytes (i.e. epidermal cells belonging to multiple adjacent EPUs), contradicting the classical EPU model. One possible problem with our earlier study was that N-ethyl-N-nitrosourea (ENU) was used to generate mutations for clonal analysis. This could alter the normal environment of the epidermal tissue and might lead to an artificial expansion of stem cell clonal lineages. In this study, we replicate our earlier findings using untreated stop-EGFP mice and relying on spontaneous mutations to generate clonal cell lineages. We propose an alternative to the classical EPU model to explain the dynamic nature of epidermal proliferation. Our niche-sharing model of EPUs allows epidermal cells to horizontally migrate among EPUs, so that multiple stem cells cooperatively maintain a larger proliferative compartment. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 838~843 | - |
dc.relation.isPartOf | EXPERIMENTAL DERMATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Lineage | - |
dc.subject.MESH | Cell Proliferation | - |
dc.subject.MESH | Clone Cells | - |
dc.subject.MESH | Codon, Terminator* | - |
dc.subject.MESH | Epidermal Cells* | - |
dc.subject.MESH | Green Fluorescent Proteins/genetics* | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Transgenic/genetics* | - |
dc.subject.MESH | Microscopy, Fluorescence/methods | - |
dc.subject.MESH | Models, Biological* | - |
dc.title | Evidence from the stop-EGFP mouse supports a niche-sharing model of epidermal proliferative units | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | Liver Cirrhosis Clinical Research Center (간경변증임상연구센터) | - |
dc.contributor.googleauthor | Simon Ro | - |
dc.contributor.googleauthor | Bruce Rannala | - |
dc.identifier.doi | 10.1111/j.1600-0625.2005.00366.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01286 | - |
dc.relation.journalcode | J00866 | - |
dc.identifier.eissn | 1600-0625 | - |
dc.identifier.pmid | 16232306 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0625.2005.00366.x/abstract | - |
dc.subject.keyword | clonal cell lineage | - |
dc.subject.keyword | epidermal proliferative unit | - |
dc.subject.keyword | in vivo imaging | - |
dc.subject.keyword | spontaneous mutation | - |
dc.subject.keyword | stop-EGFP mouse | - |
dc.contributor.alternativeName | Ro, Simon Weonsang | - |
dc.contributor.affiliatedAuthor | Ro, Simon Weonsang | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 14 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 838 | - |
dc.citation.endPage | 843 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL DERMATOLOGY, Vol.14(11) : 838-843, 2005 | - |
dc.identifier.rimsid | 46101 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.