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Dopamine transporter density in the basal ganglia assessed with [123I]IPT SPET in children with attention deficit hyperactivity disorder

Authors
 Keun-Ah Cheon  ;  Young Hoon Ryu  ;  Jong Lee  ;  Chan-Hyung Kim  ;  Kee Namkoong  ;  Young-Kee Kim 
Citation
 EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol.30(2) : 306-311, 2003 
Journal Title
 EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 
ISSN
 1619-7070 
Issue Date
2003
MeSH
[123I]IPT ; SPET ; Attention deficit hyperactivity disorder ; Basal ganglia ; Dopamine transporter
Keywords
[123I]IPT ; SPET ; Attention deficit hyperactivity disorder ; Basal ganglia ; Dopamine transporter
Abstract
Attention deficit hyperactivity disorder (ADHD) is a psychiatric disorder in childhood that is known to be associated with dopamine dysregulation. In this study, we investigated dopamine transporter (DAT) density in children with ADHD using iodine-123 labelled N-(3-iodopropen-2-yl)-2β-carbomethoxy-3β-(4-chlorophenyl) tropane ([123I]IPT) single-photon emission tomography (SPET) and postulated that an alteration in DAT density in the basal ganglia is responsible for dopaminergic dysfunction in children with ADHD. Nine drug-naive children with ADHD and six normal children were included in the study. We performed brain SPET 2 h after the intravenous administration of [123I]IPT and carried out both quantitative and qualitative analyses using the obtained SPET data, which were reconstructed for the assessment of the specific/non-specific DAT binding ratio in the basal ganglia. We then investigated the correlation between the severity scores of ADHD symptoms in children with ADHD assessed with ADHD rating scale-IV and the specific/non-specific DAT binding ratio in the basal ganglia. Drug-naive children with ADHD showed a significantly increased specific/non-specific DAT binding ratio in the basal ganglia compared with normal children. However, no significant correlation was found between the severity scores of ADHD symptoms in children with ADHD and the specific/non-specific DAT binding ratio in the basal ganglia. Our findings support the complex dysregulation of the dopaminergic neurotransmitter system in children with ADHD.
Full Text
http://link.springer.com/article/10.1007%2Fs00259-002-1047-3
DOI
10.1007/s00259-002-1047-3
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Key(김영기)
Kim, Chan Hyung(김찬형)
Namkoong, Kee(남궁기) ORCID logo https://orcid.org/0000-0003-1400-8057
Ryu, Young Hoon(유영훈) ORCID logo https://orcid.org/0000-0002-9000-5563
Lee, Jong Doo(이종두)
Cheon, Keun Ah(천근아) ORCID logo https://orcid.org/0000-0001-7113-9286
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/114680
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