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Pain Relieving Effects of KHA-30 as a Herbal Medicine in an Animal Model of Arthritis

 Bae Hwan Lee  ;  Yang-Shik Shin  ;  Sun Joon Bai  ;  Duck Mi Yoon  ;  Hye Jeong Lee  ;  Insop Shim  ;  Hyung Joon Cho 
 Korean Journal of Pain (대한통증학회지), Vol.16(2) : 198-204, 2003 
Journal Title
Korean Journal of Pain (대한통증학회지)
Issue Date
Arthritic pain ; Electrophysiological recording ; Herbal medicine ; Rat
Arthritic pain ; Electrophysiological recording ; Herbal medicine ; Rat
BACKGROUND: Herbal medicine has traditionally been used in oriental medicine to relieve pain. Arthritis, accompanied with severe pain, became the most prominent disease as more people live to advanced ages. In the present study, the effect of KHA-30 was examined in an animal model of arthritic pain induced by the injection of carrageenan into the knee joints of the rat. METHODS: Adult male Sprague-Dawley rats were used. Under urethane anesthesia, the arthritis was induced by the injection of 2% carrageenan into the left knee joint cavity of rats. To record neuronal activity of articular nerve afferents, the saphenous nerve was cut distally from the knee joint and centrally in the inguineal region. The left femur and tibia were fixed by a grip, and a mineral oil pool was made. The left saphenous artery was cannulated in order for to administer the KHA-30. Nerve fibers were characterized by their mechanical sensitivity to passive movement of the joint consisting of outward and inward movements. RESULTS: Intrarterially injected KHA-30 significantly reduced the duration of neural responses of the afferents in response to mechanical stimulation. And KHA-30 also significantly inhibited the number of neural responses to mechanical stimulation. CONCLUSIONS: These results indicate that KHA-30 may be effective in relieving arthritic pain as a herbal medicine and useful as one of the analgesics.
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1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Bai, Sun Joon(배선준) ORCID logo https://orcid.org/0000-0001-5027-3232
Shin, Yang Sik(신양식)
Yoon, Duck Mi(윤덕미)
Lee, Bae Hwan(이배환) ORCID logo https://orcid.org/0000-0003-4719-9021
Cho, Hyung Joon(조형준)
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