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Pain Relieving Effects of KHA-30 as a Herbal Medicine in an Animal Model of Arthritis

DC Field Value Language
dc.contributor.author윤덕미-
dc.contributor.author이배환-
dc.contributor.author조형준-
dc.contributor.author배선준-
dc.contributor.author신양식-
dc.date.accessioned2015-07-15T17:14:47Z-
dc.date.available2015-07-15T17:14:47Z-
dc.date.issued2003-
dc.identifier.issn2005-9159-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/114523-
dc.description.abstractBACKGROUND: Herbal medicine has traditionally been used in oriental medicine to relieve pain. Arthritis, accompanied with severe pain, became the most prominent disease as more people live to advanced ages. In the present study, the effect of KHA-30 was examined in an animal model of arthritic pain induced by the injection of carrageenan into the knee joints of the rat. METHODS: Adult male Sprague-Dawley rats were used. Under urethane anesthesia, the arthritis was induced by the injection of 2% carrageenan into the left knee joint cavity of rats. To record neuronal activity of articular nerve afferents, the saphenous nerve was cut distally from the knee joint and centrally in the inguineal region. The left femur and tibia were fixed by a grip, and a mineral oil pool was made. The left saphenous artery was cannulated in order for to administer the KHA-30. Nerve fibers were characterized by their mechanical sensitivity to passive movement of the joint consisting of outward and inward movements. RESULTS: Intrarterially injected KHA-30 significantly reduced the duration of neural responses of the afferents in response to mechanical stimulation. And KHA-30 also significantly inhibited the number of neural responses to mechanical stimulation. CONCLUSIONS: These results indicate that KHA-30 may be effective in relieving arthritic pain as a herbal medicine and useful as one of the analgesics.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageKorean-
dc.publisher대한통증학회-
dc.relation.isPartOfKorean Journal of Pain (대한통증학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHArthritic pain-
dc.subject.MESHElectrophysiological recording-
dc.subject.MESHHerbal medicine-
dc.subject.MESHRat-
dc.titlePain Relieving Effects of KHA-30 as a Herbal Medicine in an Animal Model of Arthritis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology (마취통증의학)-
dc.contributor.googleauthorBae Hwan Lee-
dc.contributor.googleauthorYang-Shik Shin-
dc.contributor.googleauthorSun Joon Bai-
dc.contributor.googleauthorDuck Mi Yoon-
dc.contributor.googleauthorHye Jeong Lee-
dc.contributor.googleauthorInsop Shim-
dc.contributor.googleauthorHyung Joon Cho-
dc.identifier.doiOAK-2003-01363-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02545-
dc.contributor.localIdA02791-
dc.contributor.localIdA03937-
dc.contributor.localIdA01795-
dc.contributor.localIdA02123-
dc.relation.journalcodeJ03702-
dc.identifier.eissn2093-0569-
dc.subject.keywordArthritic pain-
dc.subject.keywordElectrophysiological recording-
dc.subject.keywordHerbal medicine-
dc.subject.keywordRat-
dc.contributor.alternativeNameYoon, Duck Mi-
dc.contributor.alternativeNameLee, Bae Hwan-
dc.contributor.alternativeNameCho, Hyung Joon-
dc.contributor.alternativeNameBai, Sun Joon-
dc.contributor.alternativeNameShin, Yang Sik-
dc.contributor.affiliatedAuthorYoon, Duck Mi-
dc.contributor.affiliatedAuthorLee, Bae Hwan-
dc.contributor.affiliatedAuthorCho, Hyung Joon-
dc.contributor.affiliatedAuthorBai, Sun Joon-
dc.contributor.affiliatedAuthorShin, Yang Sik-
dc.rights.accessRightsfree-
dc.citation.volume16-
dc.citation.number2-
dc.citation.startPage198-
dc.citation.endPage204-
dc.identifier.bibliographicCitationKorean Journal of Pain (대한통증학회지), Vol.16(2) : 198-204, 2003-
dc.identifier.rimsid43907-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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