0 404

Cited 31 times in

Primary NK/T Cell Lymphoma of the Testis: A case report and review of the literature

Authors
 Kim Y.B.  ;  Chang S.K.  ;  Kim G.E.  ;  Suh C.O.  ;  Lee K.K.  ;  Park W.  ;  Shim S.J.  ;  Koom W.S.  ;  Hahn J.S.  ;  Yang W.-I. 
Citation
 ACTA HAEMATOLOGICA, Vol.109(2) : 95-100, 2003 
Journal Title
ACTA HAEMATOLOGICA
ISSN
 0001-5792 
Issue Date
2003
MeSH
Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Central Nervous System/pathology ; Cyclophosphamide/therapeutic use ; Doxorubicin/therapeutic use ; Fatal Outcome ; Herpesvirus 4, Human/genetics ; Humans ; Immunohistochemistry ; Immunophenotyping ; In Situ Hybridization ; Killer Cells, Natural* ; Lymphoma, T-Cell/diagnosis* ; Lymphoma, T-Cell/pathology ; Lymphoma, T-Cell/therapy ; Male ; Methotrexate/therapeutic use ; Middle Aged ; Necrosis ; Neoplasm Metastasis ; Orchiectomy ; Prednisone/therapeutic use ; RNA, Viral/analysis ; Radiotherapy ; Recurrence ; Skin/pathology ; Testicular Neoplasms/diagnosis* ; Testicular Neoplasms/pathology ; Testicular Neoplasms/therapy ; Thoracic Wall/pathology ; Tomography, X-Ray Computed ; Ultrasonography ; Vincristine/therapeutic use
Keywords
Testocular lymphoma ; NK/T cell lymphoma
Abstract
We report a case of aggressive ‘nasal type’ natural killer (NK)/T cell lymphoma initially presenting as a testicular tumor in a Korean man, which quickly took a fatal course by widespread dissemination. Histologically, the testicular mass showed a diffuse dense infiltrate of medium-sized and atypical large lymphoid cells with angiocentric and angiodestructive infiltration and areas of coagulative necrosis on hematoxylin-eosin stained sections. Immunophenotyping by immunohistochemistry yielded surface markers consistent with NK/T cell lymphoma. The Epstein-Barr virus genome was detected by in situ hybridization. During involved-field irradiation and chemotherapy following radical orchiectomy, the tumor disseminated shortly to the skin and soft tissue of his anterior chest wall and central nervous system (CNS). Identical lymphoid infiltrates were present in the patient’s skin. CNS involvement was interpreted as having a leptomeningeal seeding. To the best of our knowledge, this is the 9th reported case of confirmed NK/T cell lymphoma arising from the testis. Relevant literature is reviewed, and the clinicopathologic features, natural history, and treatment options for primary testicular NK/T cell lymphoma are discussed.
Full Text
http://www.karger.com/Article/FullText/68489
DOI
10.1159/000068489
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Kim, Gwi Eon(김귀언)
Kim, Yong Bae(김용배) ORCID logo https://orcid.org/0000-0001-7573-6862
Suh, Chang Ok(서창옥)
Shim, Su Jung(심수정)
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/113979
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links