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척수절단 후 후각망울 조직의 이식이 내림신경섬유 재생에 미치는 영향

Other Titles
 Morphological Study of the Effects of Olfactory Bulb Transplants after Complete Spinal Cord Transection 
 이원택  ;  임길병  ;  박승화  ;  이종은  ;  박경아 
 Korean Journal of Anatomy (대한해부학회지), Vol.36(4) : 247-256, 2003 
Journal Title
Korean Journal of Anatomy(대한해부학회지)
Issue Date
Tyrosine hydroxylase ; Spinal cord injury ; Transection ; Anterior horn cell ; Neurofilament protein ; Tyrosine hydroxylase ; Immunohistochemistry
척수 손상 ; 가로절단 ; 신경세사단백질 ; Tyrosine hydroxylase ; 앞뿔신경세포 ; Spinal cord injury ; Transection ; Anterior horn cell ; Neurofilament protein ; Tyrosine hydroxylase ; Immunohistochemistry
In the olfactory bulb, normal and transected olfactory axons are able to enter, regenerate, and reestablish lost synaptic contacts with their targets, throughout the lifetime of the organism. It was expected that studies of olfactory bulb ensheathing glia will provide important advances for the field of neural regeneration.
Purpose of this study is to analyze morphologically the effects of olfactory bulb transplants into the cord after complete transection. Forty Sprague-Dawley rats were used in this study. Spinal cord of the rats were transected after laminectomy followed by insertion of chopped olfactory bulb tissues immediately and 3 weeks after the operation.
In this study, transplants of olfactory bulb were successfully used to promote functional and structural recovery after complete spinal cord transection. The area of damaged spinal cord was greatly diminished after olfactory bulb transplantation. Nearly normal anterior horn cells were observed immediately distal to the transected region. Tyrosine
hydroxylase immunoreactive descending fibers were observed in the distal region beyond transected area.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Park, Kyung Ah(박경아)
Lee, Jong Eun(이종은) ORCID logo https://orcid.org/0000-0001-6203-7413
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