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뇌허혈 손상모델에서 HPLC를 이용한 Agmatine의 정량

Other Titles
 Quantitative Analysis of Agmatine by HPLC in Ischemic Brain 
Authors
 홍종순  ;  전혁  ;  이종은  ;  박경아  ;  이원택  ;  김재환  ;  정효석 
Citation
 Korean Journal of Anatomy (대한해부학회지), Vol.36(3) : 257-264, 2003 
Journal Title
Korean Journal of Anatomy(대한해부학회지)
ISSN
 1225-1305 
Issue Date
2003
MeSH
Agmatine ; MCA occlusion ; Agmatine ; Cerebral ischemia ; Reperfusion ; Neuroprotective effect ; MCAO
Keywords
Agmatine ; 뇌허혈 ; MCA occlusion ; 재관류 ; 신경보호효과 ; Agmatine ; Cerebral ischemia ; Reperfusion ; Neuroprotective effect ; MCAO
Abstract
Agmatine, a widely distributed molecule in mammalian tissues, shows neuroprotective effects in brain ischemia. We describe the neuroprotective effects of agmatine in the mouse MCAO model and the quantitative change of agmatine in ischemic injury. Brain ischemic injured mice were injected with agmatine (100 mg/kg of mouse, IP). Agmatine significantly reduced the infarct area after MCAO. Despite the similar patterns of agmatine change observed in control or agmatine injected animals, the agmatine levels of the penumbra were significantly higher than those of the striatum and the cerebral cortex during the early period (⁄1 hour after 2 hours of MCA occlusion). This suggests that the early period, during which agmatine levels increase in the brain, is the crucial period in terms of neuroprotective effect during ischemia.
Full Text
http://scholar.dkyobobook.co.kr/searchDetail.laf?barcode=4010022938887
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Park, Kyung Ah(박경아)
Lee, Jong Eun(이종은) ORCID logo https://orcid.org/0000-0001-6203-7413
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/113781
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