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Usefulness of 18F-FDG PET in intrahepatic cholangiocarcinoma

Authors
 Young-Jin Kim  ;  Mijin Yun  ;  Jong Doo Lee  ;  Kyung Sik Kim  ;  Woo Jung Lee 
Citation
 EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol.30(11) : 1467-1472, 2003 
Journal Title
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
ISSN
 1619-7070 
Issue Date
2003
MeSH
Adult ; Aged ; Bile Duct Neoplasms/classification ; Bile Duct Neoplasms/diagnostic imaging* ; Bile Duct Neoplasms/pathology ; Bile Ducts, Intrahepatic/diagnostic imaging* ; Bile Ducts, Intrahepatic/pathology ; Cholangiocarcinoma/classification ; Cholangiocarcinoma/diagnostic imaging* ; Cholangiocarcinoma/pathology ; Female ; Fluorodeoxyglucose F18* ; Humans ; Male ; Middle Aged ; Neoplasm Staging/methods ; Radiopharmaceuticals ; Reproducibility of Results ; Sensitivity and Specificity ; Tomography, Emission-Computed/methods*
Abstract
Surgical resection is the only curative treatment strategy for intrahepatic cholangiocarcinoma (CC). Therefore, accurate staging is essential for appropriate management of patients with CC. We assessed the usefulness of 2-[18F]fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET) in the staging of CC. We undertook a retrospective review of FDG PET images in 21 patients (10 female, 11 male; mean age 57 years) diagnosed with CC. Ten patients had hilar CC and 11, peripheral CC. Patients underwent abdominal magnetic resonance imaging (MRI) (n=20) and computed tomography (CT) (n=12) for the evaluation of primary tumours, and chest radiography and whole-body bone scintigraphy for work-up of distant metastases. For semi-quantitative analysis, the maximum voxel standardised uptake value (SUVmax) was obtained from the primary tumour. All peripheral CCs showed intensely increased FDG uptake, and some demonstrated ring-shaped uptake corresponding to peripheral rim enhancement on CT and/or MRI. In nine of the ten patients, hilar CCs demonstrated increased FDG uptake of a focal nodular or linear branching appearance. The remaining case was false negative on FDG PET. One patient with a false negative result on MRI demonstrated increased uptake on FDG PET. Among the ten hilar CCs, FDG uptake was intense in only two patients and was slightly higher than that of the hepatic parenchyma in the remaining patients. For the detection of lymph node metastasis, FDG PET and CT/MRI were concordant in 16 patients, and discordant in five (FDG PET was positive in three, and CT and MRI in two). FDG PET identified unsuspected distant metastases in four of the 21 patients; all of these patients had peripheral CC. FDG PET is useful in detecting the primary lesion in both hilar and peripheral CC and is of value in discovering unsuspected distant metastases in patients with peripheral CC. FDG PET could be useful in cases of suspected hilar CC with non-confirmatory biopsy and radiological findings.
Full Text
http://link.springer.com/article/10.1007%2Fs00259-003-1297-8
DOI
10.1007/s00259-003-1297-8
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Sik(김경식) ORCID logo https://orcid.org/0000-0001-9498-284X
Kim, Young Jin(김영진) ORCID logo https://orcid.org/0000-0002-6235-6550
Kim, Young Tae(김영태) ORCID logo https://orcid.org/0000-0002-7347-1052
Lee, Jong Doo(이종두)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/113683
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