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벤젠 대사에 있어서 GST Subfamily와 NQO1 유전자다형성의 영향

Other Titles
 Influences of GST Subfamily & NQO1 Gene Polymorphism on the Metabolism of Benzene 
Authors
 정효석  ;  김기웅  ;  장성근  ;  박경아  ;  이원택  ;  이종은 
Citation
 Korean Journal of Anatomy (대한해부학회지), Vol.36(3) : 291-299, 2003 
Journal Title
Korean Journal of Anatomy(대한해부학회지)
ISSN
 1225-1305 
Issue Date
2003
MeSH
Benzene ; phenol ; glutathione S-transferase (GST) ; NAD(P)H ; quinone oxidoreductase 1 (NQO1)
Keywords
Benzene ; phenol ; glutathione S-transferase (GST) ; NAD(P)H ; quinone oxidoreductase 1 (NQO1)
Abstract
The higher concentration of traces of aromatic hydrocarbons prevailing in the refinery atmosphere causes severe occupational health hazard to refinery workers. In this study, the biochemical role of genetic polymorphism in modulating urinary excretion of benzene metabolite as phenol level has been investigated in 90 workers exposed to benzene in the petroleum refinery plants of Korea. Glutathione S-transferase (GST) subfamily as GSTM1, GSTT1 and GSTP1 and NAD(P)H: quinone oxidoreductase 1 (NQO1) gene polymorphisms were determined by polymerase chain reaction (PCR)-based methods. The mean concentration of volatile benzene in the refinery environment was 0.042 mg/m3 (SD, 0.069) and that of urinary phenol was 7.42 mg/g creatinine (SD, 11.3). The airborne benzene concentration was significantly related to the concentration of phenol in urine (r = 0.640, p⁄0.01).
However, all the genotypes of GST subfamily and NQO1 except small sample size of genotypes in GSTM1 and GSTT1 none of them were higher than that of present genotype. Also, it was higher in the GSTP1*1/*1 than in the GSTP1*1/*2.
The various biological (i.e. age and liver function parameters) or lifestyle factors (i.e. medication, smoking, alcohol and coffee intake), also taken into account as potential confounders, did not influence the correlations found.
These results suggested that GST subfamily and NQO1 genotypes might play an important role in the metabolism of benzene.
Full Text
http://scholar.dkyobobook.co.kr/searchDetail.laf?barcode=4010022939998
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Park, Kyung Ah(박경아)
Lee, Jong Eun(이종은) ORCID logo https://orcid.org/0000-0001-6203-7413
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/113544
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