Alcohol use disorders and related problems continue to constitute a significant public health problem, leading to many psychi-atiic conditions, physical illnesses, and social problems such as domestic violence and occupational disabilities. Here, we provide an update on alcohol use disorders ; 1) genetic and neurobiological aspect, 2) neuroimaging study findings, 3) treatment of medical complications 4) psychotherapeutic approaches 5) pharmacological treatment and 6) women and offsprings issues of alcohol use disorders.