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Normal serum aminotransferase concentration and risk of mortality from liver diseases: Prospective cohort study

 Hyeon Chang Kim  ;  Chung Mo Nam  ;  Il Suh  ;  Dae Kyu Oh  ;  Kwang Hyub Han  ;  Sun Ha Jee 
 BMJ-BRITISH MEDICAL JOURNAL, Vol.328(7446) : 983-986, 2004 
Journal Title
Issue Date
Adult ; Epidemiologic Methods ; Female ; Humans ; Korea/epidemiology ; Liver Diseases/enzymology* ; Liver Diseases/mortality ; Male ; Middle Aged ; Prognosis ; Sex Distribution ; Transaminases/blood*
OBJECTIVE: To examine the relation between the normal range of serum aminotransferase concentration and mortality from liver disease.
DESIGN: Prospective cohort study.
SETTING: Korea Medical Insurance Corporation study with eight years' follow up.
PARTICIPANTS: 94,533 men and 47,522 women aged 35-59 years.
MAIN OUTCOME MEASURE: Mortality from liver diseases according to death certificate.
RESULTS: There was a positive association between the aminotransferase concentration, even within normal range (35-40 IU/l), and mortality from liver disease. Compared with the concentration < 20 IU/l, the adjusted relative risks for an aspartate aminotransferase concentration of 20-29 IU/l and 30-39 IU/l were 2.5 (95% confidence interval 2.0 to 3.0) and 8.0 (6.6 to 9.8) in men and 3.3 (1.7 to 6.4) and 18.2 (8.1 to 40.4) in women, respectively, The corresponding risks for alanine aminotransferase were 2.9 (2.4 to 3.5) and 9.5 (7.9 to 11.5) in men and 3.8 (1.9 to 7.7) and 6.6 (1.5 to 25.6) in women, respectively. According to receiver operating characteristic curves the best cut-off values for the prediction of liver disease in men were 31 IU/l for aspartate aminotransferase and 30 IU/l for alanine aminotransferase.
CONCLUSION: People with slightly increased aminotransferase activity, but still within the normal range, should be closely observed and further investigated for liver diseases.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Kim, Hyeon Chang(김현창) ORCID logo https://orcid.org/0000-0001-7867-1240
Nam, Chung Mo(남정모) ORCID logo https://orcid.org/0000-0003-0985-0928
Suh, Il(서일) ORCID logo https://orcid.org/0000-0002-9689-7849
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
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